Clostridioides (Clostridium) difficile infection burden in Japan: A multicenter prospective study.
Clostridioides (Clostridium) difficile
Incidence rate
Japan
PCR-Ribotype 018
Journal
Anaerobe
ISSN: 1095-8274
Titre abrégé: Anaerobe
Pays: England
ID NLM: 9505216
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
27
12
2018
revised:
19
02
2019
accepted:
06
03
2019
pubmed:
16
3
2019
medline:
21
4
2020
entrez:
16
3
2019
Statut:
ppublish
Résumé
Clostridioides (Clostridium) difficile is the leading cause of healthcare-associated infectious diarrhea in the developed world. Retrospective studies have shown a lower incidence of C. difficile infection (CDI) in Japan than in Europe or North America. Prospective studies are needed to determine if this is due lack of testing for C. difficile or a true difference in CDI epidemiology. A prospective cohort study of CDI was conducted from May 2014 to May 2015 at 12 medical facilities (20 wards) in Japan. Patients with at least three diarrheal bowel movements (Bristol stool grade 6-7) in the preceding 24 h were enrolled. CDI was defined by positive result on enzyme immunoassay for toxins A/B, nucleic acid amplification test for the toxin B gene or toxigenic culture. C. difficile isolates were subjected to PCR-ribotyping (RT), slpA-sequence typing (slpA-ST), and antimicrobial susceptibility testing. The overall incidence of CDI was 7.4/10,000 patient-days (PD). The incidence was highest in the five ICU wards (22.2 CDI/10,000 PD; range: 13.9-75.5/10,000 PD). The testing frequency and CDI incidence rate were highly correlated (R
Identifiants
pubmed: 30872073
pii: S1075-9964(19)30046-0
doi: 10.1016/j.anaerobe.2019.03.007
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
102011Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.