Mandibular advancement reveals long-term suppression of breathing discomfort in patients with obstructive sleep apnea syndrome.
Breathing discomfort
Gating out
Latent dyspnoea
Mandibular advancement device
Obstructive sleep apnoea syndrome
Sensory habituation
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
12
12
2018
revised:
08
03
2019
accepted:
10
03
2019
pubmed:
16
3
2019
medline:
18
12
2019
entrez:
16
3
2019
Statut:
ppublish
Résumé
Obstructive sleep apnoea syndrome (OSAS) patients do not report breathing discomfort in spite of abnormal upper airway mechanics. We studied respiratory sensations in OSAS patients without and with mandibular advancement device (MAD). Fifty-seven moderate to severe non obese OSAS patients were asked about breathing discomfort using visual analogue scales (VAS) in the sitting position (VAS-1), after lying down (VAS-2), then with MAD (VAS-3). Awake critical closing pressure (awake Pcrit) was measured in 15 patients without then with MAD. None of the patients reported breathing discomfort when sitting but 19 patients (33%) did when lying (VAS-2: -20% or less). A feeling of "easier breathing" with MAD was observed and was more marked in patients reporting breathing discomfort when supine (VAS-3: +66.0% [49.0; 89.0]) than in those not doing so (VAS-3: +28.5% [1.0; 56.5], p = 0.007). MAD-induced change in awake Pcrit was correlated to VAS-3. In conclusion, MAD revealed "latent dyspnea" related to the severity of upper airways mechanics abnormalities in OSAS patients.
Identifiants
pubmed: 30872167
pii: S1569-9048(18)30425-7
doi: 10.1016/j.resp.2019.03.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-54Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.