Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies.
Adult
Antibodies, Anti-Idiotypic
/ blood
Blood Group Incompatibility
/ diagnosis
Cesarean Section
/ methods
Cholestasis
/ diagnosis
Combined Modality Therapy
Elective Surgical Procedures
Erythroblastosis, Fetal
/ diagnosis
Female
Follow-Up Studies
Gestational Age
Humans
Immunoglobulin G
/ blood
Infant, Newborn
Pregnancy
Pregnancy Complications, Hematologic
/ diagnosis
Pregnancy, High-Risk
Severity of Illness Index
Time Factors
Treatment Outcome
Journal
Pediatrics
ISSN: 1098-4275
Titre abrégé: Pediatrics
Pays: United States
ID NLM: 0376422
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
accepted:
15
11
2018
pubmed:
16
3
2019
medline:
8
11
2019
entrez:
16
3
2019
Statut:
ppublish
Résumé
ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O/A HDFN associated with extremely high-titer (1:32 000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. After exclusion of an underlying disease and other risk factors, cholestasis resolved after treatment with ursodeoxycholic acid, a red blood cell transfusion, and intravenous immunoglobulins. This case is presented to create awareness for a more severe course of ABO HDFN in nonwhite and non-European mother-child pairs.
Identifiants
pubmed: 30872329
pii: peds.2018-2859
doi: 10.1542/peds.2018-2859
pii:
doi:
Substances chimiques
Antibodies, Anti-Idiotypic
0
Immunoglobulin G
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 by the American Academy of Pediatrics.
Déclaration de conflit d'intérêts
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.