Acute myeloid leukaemia: an unusual cause of biliary strictures.
Adolescent
Antibiotics, Antineoplastic
/ therapeutic use
Antimetabolites, Antineoplastic
/ therapeutic use
Bile Ducts, Extrahepatic
/ diagnostic imaging
Cholangiography
/ methods
Cholangitis
/ diagnosis
Cholestasis
/ etiology
Constriction, Pathologic
Cytarabine
/ administration & dosage
Daunorubicin
/ administration & dosage
Drug Therapy
/ methods
Humans
Jaundice, Obstructive
/ etiology
Leukemia, Myeloid, Acute
/ complications
Male
Treatment Outcome
liver disease
malignant and benign haematology
pancreas and biliary tract
radiology
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
14 Mar 2019
14 Mar 2019
Historique:
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
27
6
2019
Statut:
epublish
Résumé
A 17-year-old man with no significant past medical history presented with a 2-week history of worsening jaundice, lethargy, anorexia and progressive right upper quadrant abdominal pain. There were no stigmata of chronic liver disease. Initial investigations were suggestive of cholangitis with large intrahepatic and extrahepatic bile duct strictures but otherwise normal hepatic and splenic appearances. A percutaneous transhepatic cholangiogram with the positioning of drains was performed to alleviate the obstructive jaundice. Within 2 weeks of the first presentation, full blood count revealed a significantly raised white blood count and a subsequent peripheral blood smear and bone marrow were consistent with a diagnosis of acute myeloid leukaemia. Chemotherapy was started after partial improvement of his obstructive jaundice. Complete morphological and cytogenetic remission was obtained 4 weeks after the first cycle of chemotherapy (half dose of daunorubicin and full dose of cytarabine, treated off trial) on control bone marrow. The patient remains in remission.
Identifiants
pubmed: 30872340
pii: 12/3/e227821
doi: 10.1136/bcr-2018-227821
pmc: PMC6424271
pii:
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Antimetabolites, Antineoplastic
0
Cytarabine
04079A1RDZ
Daunorubicin
ZS7284E0ZP
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Clin Pathol. 2004 May;57(5):544-5
pubmed: 15113866