Acoel genome reveals the regulatory landscape of whole-body regeneration.

Animals Binding Sites Chromatin / metabolism Early Growth Response Transcription Factors / metabolism Gene Expression Regulation Gene Regulatory Networks Genome Invertebrates / genetics Regeneration / genetics Transcriptome Wound Healing / genetics

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
15 03 2019
Historique:
received: 28 06 2018
revised: 08 11 2018
accepted: 08 02 2019
entrez: 16 3 2019
pubmed: 16 3 2019
medline: 14 8 2019
Statut: ppublish

Résumé

Whole-body regeneration is accompanied by complex transcriptomic changes, yet the chromatin regulatory landscapes that mediate this dynamic response remain unexplored. To decipher the regulatory logic that orchestrates regeneration, we sequenced the genome of the acoel worm

Identifiants

DOI: 10.1126/science.aau6173 PMID: 30872491
pubmed: 30872491
pii: 363/6432/eaau6173
doi: 10.1126/science.aau6173
pii:
doi:

Substances chimiques

Chromatin 0
Early Growth Response Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD080708
Pays : United States
Organisme : NLM NIH HHS
ID : T32 LM012417
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Andrew R Gehrke (AR)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-6588-3890

Emily Neverett (E)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

Yi-Jyun Luo (YJ)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-3418-3146

Alexander Brandt (A)

Department of Chemistry, University of California, Berkeley, CA 94703, USA.

Lorenzo Ricci (L)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-1547-0844

Ryan E Hulett (RE)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0001-9288-7099

Annika Gompers (A)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-2591-3477

J Graham Ruby (JG)

Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

Daniel S Rokhsar (DS)

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94703, USA.
ORCID: 0000-0002-8704-2224

Peter W Reddien (PW)

Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.
ORCID: 0000-0002-5569-333X

Mansi Srivastava (M)

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. mansi@oeb.harvard.edu.
Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
ORCID: 0000-0002-2126-8634

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription EGR › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Acoel genome reveals the regulatory landscape...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Acoel genome reveals the regulatory landscape...