Immune Activations and Viral Tissue Compartmentalization During Progressive HIV-1 Infection of Humanized Mice.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 10 08 2018
accepted: 08 02 2019
entrez: 16 3 2019
pubmed: 16 3 2019
medline: 15 7 2020
Statut: epublish

Résumé

Human immunodeficiency virus type one (HIV-1) tissue compartments are established soon after viral infection. However, the timing in which virus gains a permanent foothold in tissue and the cellular factors that control early viral-immune events are incompletely understood. These are critical events in studies of HIV-1 pathogenesis and in the development of viral reservoirs after antiretroviral therapy. Moreover, factors affecting the permanence of viral-tissue interactions underlie barriers designed to eliminate HIV-1 infection. To this end we investigated the temporal and spatial viral and host factors during HIV-1 seeding of tissue compartments. Two humanized NOD.Cg-Prkdc

Identifiants

pubmed: 30873181
doi: 10.3389/fimmu.2019.00340
pmc: PMC6403174
doi:

Substances chimiques

Viral Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

340

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS036126
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA028555
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062261
Pays : United States
Organisme : NIDA NIH HHS
ID : P01 DA037830
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043540
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034239
Pays : United States
Organisme : NIH HHS
ID : R24 OD018546
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH110360
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH115860
Pays : United States

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Auteurs

Hang Su (H)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Yan Cheng (Y)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Sruthi Sravanam (S)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Saumi Mathews (S)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Santhi Gorantla (S)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Larisa Y Poluektova (LY)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Prasanta K Dash (PK)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Howard E Gendelman (HE)

Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, United States.

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Classifications MeSH