Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression.
Adult
Aged
Aquaporin 4
/ metabolism
Biopsy
Brain Neoplasms
/ metabolism
Chemoradiotherapy
/ methods
Disease Progression
Edema
/ metabolism
Female
Gene Expression Regulation, Neoplastic
/ physiology
Glioblastoma
/ metabolism
Glioma
/ metabolism
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
/ metabolism
Retrospective Studies
AQP4
Aquaporin-4
Edema
Glioblastoma
Journal
Cancer investigation
ISSN: 1532-4192
Titre abrégé: Cancer Invest
Pays: England
ID NLM: 8307154
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
16
3
2019
medline:
30
3
2019
entrez:
16
3
2019
Statut:
ppublish
Résumé
There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. In addition, there was no clear relationship between AQP4 expression and degree of edema.
Identifiants
pubmed: 30873889
doi: 10.1080/07357907.2018.1564927
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM