Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.
Animals
Disease Resistance
/ genetics
Female
Fibroblasts
GTP Phosphohydrolases
/ genetics
HEK293 Cells
Host-Parasite Interactions
/ genetics
Humans
Male
Mice
Mice, Inbred C57BL
Protein Isoforms
Protozoan Proteins
/ genetics
Selection, Genetic
/ immunology
Toxoplasma
/ immunology
Toxoplasmosis, Animal
/ immunology
Virulence
/ immunology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 03 2019
15 03 2019
Historique:
received:
04
06
2018
accepted:
27
02
2019
entrez:
16
3
2019
pubmed:
16
3
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains. In some wild-derived Eurasian mice (such as CIM) on the other hand, polymorphic IRG proteins inhibit the replication of such virulent T. gondii strains. Here we show that this resistance is due to direct binding of the IRG protein Irgb2-b1
Identifiants
pubmed: 30874554
doi: 10.1038/s41467-019-09200-2
pii: 10.1038/s41467-019-09200-2
pmc: PMC6420625
doi:
Substances chimiques
Protein Isoforms
0
Protozoan Proteins
0
GTP Phosphohydrolases
EC 3.6.1.-
Gm12185 protein, mouse
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1233Commentaires et corrections
Type : ErratumIn
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