Assessing Blood Clotting and Coagulation Factors in Mice.

Animals Blood Coagulation Blood Coagulation Factors / metabolism Blood Coagulation Tests / instrumentation Mice / blood Mice, Inbred Strains Tail Time Factors
bleeding blood coagulation hemostasis mouse models thrombosis

Journal

Current protocols in mouse biology
ISSN: 2161-2617
Titre abrégé: Curr Protoc Mouse Biol
Pays: United States
ID NLM: 101560384

Informations de publication

Date de publication:
Jun 2019
Historique:
pubmed: 16 3 2019
medline: 23 10 2019
entrez: 16 3 2019
Statut: ppublish

Résumé

The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism. Blood coagulation activity in inbred mouse strains varies widely among strains, suggesting that many genomic variants affect hemostasis. Some of these molecules have been discovered and characterized; however, many are still unknown. Genetically modified mouse technologies are providing a plethora of new mouse models for investigating the regulation of blood coagulation. Here we provide a protocol for the tail bleeding time as a primary assessment of in vivo blood coagulation, as well as in vitro methods such as the prothrombin time, activated partial thromboplastin time, and thrombin generation assay. We also provide protocols for the assessment of the activities of specific known factors involved in blood coagulation. © 2019 by John Wiley & Sons, Inc.

Identifiants

DOI: 10.1002/cpmo.61 PMID: 30875463 PMC: PMC6771260
pubmed: 30875463
doi: 10.1002/cpmo.61
pmc: PMC6771260
mid: NIHMS1014625
doi:

Substances chimiques

Blood Coagulation Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e61

Subventions

Organisme : National Heart, Lung, and Blood Institute (NHLBI)
ID : R01-HL135035
Organisme : American Heart Association
ID : 17IRG33460238
Organisme : National Heart, Lung, and Blood Institute (NHLBI)
ID : R15-HL133907
Organisme : NIH HHS
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135035
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL068835
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01-HL068835
Pays : United States
Organisme : NHLBI NIH HHS
ID : R15 HL133907
Pays : United States

Informations de copyright

© 2019 John Wiley & Sons, Inc.

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Auteurs

Marisa A Brake (MA)

Department of Biological Sciences, Oakland University, Rochester, Michigan.

Lacramioara Ivanciu (L)

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Divison of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Susan A Maroney (SA)

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin.

Nicolas D Martinez (ND)

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin.

Alan E Mast (AE)

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin.
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin.

Randal J Westrick (RJ)

Department of Biological Sciences, Oakland University, Rochester, Michigan.
Center for Data Science and Big Data Analysis, Center for Biomedical Research, Oakland University, Rochester, Michigan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Tests de coagulation sanguine › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Structures anatomiques de l'animal › Queue › Assessing Blood Clotting and Coagulation...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Assessing Blood Clotting and Coagulation...