'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency.
Amino Acid Sequence
Amino Acids
/ chemistry
Animals
COS Cells
Cell Line
Chlorocebus aethiops
Conotoxins
/ chemistry
Conus Snail
/ chemistry
Fluorenes
/ chemistry
Humans
Mollusk Venoms
/ chemistry
Norepinephrine Plasma Membrane Transport Proteins
/ antagonists & inhibitors
Peptides
/ chemical synthesis
MrIA
Norepinephrine Transporter Inhibitor (NET)
bioactivity
conotoxin
peptides
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
14 Mar 2019
14 Mar 2019
Historique:
received:
01
02
2019
revised:
26
02
2019
accepted:
12
03
2019
entrez:
17
3
2019
pubmed:
17
3
2019
medline:
30
7
2019
Statut:
epublish
Résumé
Integrated venomics techniques have shown that variable processing of conotoxins from
Identifiants
pubmed: 30875751
pii: md17030165
doi: 10.3390/md17030165
pmc: PMC6470548
pii:
doi:
Substances chimiques
Amino Acids
0
Conotoxins
0
Fluorenes
0
Mollusk Venoms
0
N(alpha)-fluorenylmethyloxycarbonylamino acids
0
Norepinephrine Plasma Membrane Transport Proteins
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : Program Grant APP1072113
Références
Nat Neurosci. 2001 Sep;4(9):902-7
pubmed: 11528421
J Biol Chem. 2003 Oct 10;278(41):40324-9
pubmed: 12837768
J Biol Chem. 2003 Oct 10;278(41):40317-23
pubmed: 12885787
Nat Rev Drug Discov. 2003 Oct;2(10):790-802
pubmed: 14526382
IUBMB Life. 2004 Feb;56(2):89-93
pubmed: 15085932
Chem Biol. 2009 Feb 27;16(2):153-61
pubmed: 19246006
J Med Chem. 2009 Nov 26;52(22):6991-7002
pubmed: 19860431
Toxicon. 2012 Mar 15;59(4):524-8
pubmed: 21839105
Int J Pept Protein Res. 1990 Mar;35(3):161-214
pubmed: 2191922
Biochem Pharmacol. 2012 Jun 1;83(11):1562-71
pubmed: 22410003
Mol Cell Proteomics. 2013 Feb;12(2):312-29
pubmed: 23152539
PLoS One. 2013;8(3):e59293
pubmed: 23536870
BMC Genomics. 2013 Oct 16;14:708
pubmed: 24131469
Chem Rev. 2014 Jun 11;114(11):5815-47
pubmed: 24720541
Future Med Chem. 2014 Oct;6(15):1659-75
pubmed: 25406006
Mol Pain. 2016 Apr 29;12:null
pubmed: 27130590