The Therapeutic Potential of Apigenin.
apigenin
cancer
chronic diseases
diabetes
flavonoids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Mar 2019
15 Mar 2019
Historique:
received:
11
02
2019
revised:
05
03
2019
accepted:
06
03
2019
entrez:
17
3
2019
pubmed:
17
3
2019
medline:
4
7
2019
Statut:
epublish
Résumé
Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. The present work is an updated overview of apigenin, focusing on its health-promoting effects/therapeutic functions and, in particular, results of in vivo research. In addition to an introduction to its chemistry, nutraceutical features have also been described. The main key findings from in vivo research, including animal models and human studies, are summarized. The beneficial indications are reported and discussed in detail, including effects in diabetes, amnesia and Alzheimer's disease, depression and insomnia, cancer, etc. Finally, data on flavonoids from the main public databases are gathered to highlight the apigenin's key role in dietary assessment and in the evaluation of a formulated diet, to determine exposure and to investigate its health effects in vivo.
Identifiants
pubmed: 30875872
pii: ijms20061305
doi: 10.3390/ijms20061305
pmc: PMC6472148
pii:
doi:
Substances chimiques
Apigenin
7V515PI7F6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Database (Oxford). 2012 Aug 09;2012:bas031
pubmed: 22879444
Bioorg Med Chem. 2014 Mar 1;22(5):1515-21
pubmed: 24508143
Int J Oncol. 2007 Jan;30(1):233-45
pubmed: 17143534
Biopharm Drug Dispos. 2015 Oct;36(7):440-51
pubmed: 25904312
Chem Biol Interact. 2009 May 15;179(2-3):407-12
pubmed: 19070612
Oxid Med Cell Longev. 2016;2016:1594616
pubmed: 26843906
Eur J Clin Nutr. 2010 Nov;64 Suppl 3:S101-7
pubmed: 21045837
Free Radic Biol Med. 2002 Mar 1;32(5):386-93
pubmed: 11864778
Front Plant Sci. 2012 Sep 28;3:222
pubmed: 23060891
Database (Oxford). 2013 Oct 07;2013:bat070
pubmed: 24103452
Molecules. 2018 Jul 28;23(8):
pubmed: 30060557
Mol Hum Reprod. 2013 Jul;19(7):451-62
pubmed: 23475986
Database (Oxford). 2010;2010:bap024
pubmed: 20428313
Phytomedicine. 2016 Dec 15;23(14):1735-1742
pubmed: 27912875
Microbiol Res. 2018 Oct;215:76-88
pubmed: 30172312
Pak J Pharm Sci. 2013 Sep;26(5):999-1008
pubmed: 24035959
Annu Rev Nutr. 2002;22:19-34
pubmed: 12055336
BMC Complement Altern Med. 2011 Sep 22;11:78
pubmed: 21939549
Plant Physiol. 1995 Jan;107(1):7-12
pubmed: 7870841
Expert Rev Clin Pharmacol. 2018 Jun;11(6):545-547
pubmed: 29667442
Phytochemistry. 2001 Sep;58(1):43-6
pubmed: 11524111
Biochem Biophys Res Commun. 1990 Sep 28;171(3):1199-204
pubmed: 1977385
Cancer Res. 2007 Jul 15;67(14):6925-35
pubmed: 17638904
Sci Rep. 2016 Aug 12;6:31450
pubmed: 27514990
J Pharm Biomed Anal. 2018 Feb 5;149:488-493
pubmed: 29182998
Sci Rep. 2018 Apr 3;8(1):5471
pubmed: 29615674
Int J Oncol. 2005 Jan;26(1):185-9
pubmed: 15586239
Iran J Pharm Res. 2019 Winter;18(1):168-182
pubmed: 31089353
Molecules. 2013 Aug 19;18(8):9949-65
pubmed: 23966081
Br J Nutr. 1999 Jun;81(6):447-55
pubmed: 10615220
Nat Prod Res. 2016;30(8):920-5
pubmed: 26327252
Wei Sheng Yan Jiu. 2010 Nov;39(6):693-6, 700
pubmed: 21351633
Biomol Ther (Seoul). 2016 Nov 1;24(6):630-637
pubmed: 27302962
Int J Pharm. 2012 Oct 15;436(1-2):311-7
pubmed: 22796171
Rev Neurol. 2010 May 1;50(9):520-8
pubmed: 20443170
Am J Epidemiol. 1997 Aug 1;146(3):223-30
pubmed: 9247006
World J Gastroenterol. 2008 Apr 14;14(14):2187-93
pubmed: 18407592
Nat Prod Res. 2016;30(8):912-9
pubmed: 26327332
J Neuroinflammation. 2008 Sep 25;5:41
pubmed: 18817573
Expert Rev Clin Pharmacol. 2019 Jan;12(1):1-7
pubmed: 30484336
J Neurol Neurophysiol. 2014 Aug;5(4):
pubmed: 25364620
Life Sci. 2008 Mar 26;82(13-14):741-51
pubmed: 18308340
Mol Med Rep. 2018 Aug;18(2):1560-1570
pubmed: 29901074
Phytother Res. 2018 Nov;32(11):2202-2213
pubmed: 30080294
Biochem Pharmacol. 2000 Jun 1;59(11):1387-94
pubmed: 10751547
J Biomed Sci. 2009 May 27;16:49
pubmed: 19473507
Nat Prod Rep. 2003 Feb;20(1):79-110
pubmed: 12636085
Complement Ther Clin Pract. 2015 Aug;21(3):181-7
pubmed: 26256137
Int J Cancer. 2000 Aug 15;87(4):595-600
pubmed: 10918203
Phytother Res. 2009 Nov;23(11):1642-4
pubmed: 19441011
Arch Pharm Res. 2007 Oct;30(10):1318-27
pubmed: 18038911
Nat Prod Res. 2019 May;33(10):1500-1503
pubmed: 29338358
Carcinogenesis. 2014 Feb;35(2):452-60
pubmed: 24067903
Planta Med. 2002 Oct;68(10):934-6
pubmed: 12391561
Molecules. 2018 Dec 08;23(12):
pubmed: 30544820
Arch Med Res. 2014 Nov;45(8):610-38
pubmed: 25481827
Int J Cancer. 2008 Aug 15;123(4):895-8
pubmed: 18491402
Eur J Pharmacol. 2016 Feb 15;773:13-23
pubmed: 26801071
Cancer Lett. 2018 Jan 28;413:11-22
pubmed: 29097249
Pharm Biol. 2015;53(10):1505-10
pubmed: 25853956
Pharm Res. 2012 Jun;29(6):1506-17
pubmed: 22139534
Biol Pharm Bull. 2003 Apr;26(4):474-80
pubmed: 12673028
Top Curr Chem (Cham). 2018 Jan 17;376(1):3
pubmed: 29344754
Molecules. 2012 Sep 03;17(9):10503-39
pubmed: 22945029
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
J Immunol. 2007 Nov 15;179(10):7121-7
pubmed: 17982104
Int J Pharm. 2017 Nov 5;532(2):757-768
pubmed: 28456651
Evid Based Complement Alternat Med. 2016;2016:8243215
pubmed: 27594892
Chem Biodivers. 2018 Aug;15(8):e1800148
pubmed: 29790302
Neural Regen Res. 2015 Aug;10(8):1181-5
pubmed: 26487830
Life Sci. 2006 May 15;78(25):2872-88
pubmed: 16325868
J Pharm Pharmacol. 2007 Nov;59(11):1543-8
pubmed: 17976266
Eur J Pharmacol. 1996 Sep 26;312(2):203-7
pubmed: 8894597
J Pharm Pharmacol. 2000 Apr;52(4):451-9
pubmed: 10813558
Anticancer Res. 2014 Jun;34(6):2869-82
pubmed: 24922650
J Alzheimers Dis. 2011;24(1):85-100
pubmed: 21297270
Oxid Med Cell Longev. 2013;2013:704310
pubmed: 24069504
Pharm Res. 2010 Jun;27(6):962-78
pubmed: 20306120
J Nanosci Nanotechnol. 2013 Oct;13(10):6546-52
pubmed: 24245113
Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S184-93
pubmed: 19035558
Mol Cancer Ther. 2005 Jan;4(1):1-11
pubmed: 15657348
Ther Adv Drug Saf. 2015 Aug;6(4):151-65
pubmed: 26301069
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt B):799-813
pubmed: 24056053
Sleep Med Rev. 2015 Dec;24:1-12
pubmed: 25644982
Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S151-83
pubmed: 19065581
Oxid Med Cell Longev. 2015;2015:181260
pubmed: 26180580
Oxid Med Cell Longev. 2017;2017:6986143
pubmed: 29250301
Foods. 2017 Sep 05;6(9):
pubmed: 28872585
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):805-8
pubmed: 15824147
Int J Oncol. 2013 Nov;43(5):1675-82
pubmed: 23969487
Mol Cell Biochem. 2012 Jul;366(1-2):319-34
pubmed: 22527937
Pharmacol Res. 2018 Feb;128:359-365
pubmed: 29055745
J Med Food. 2010 Apr;13(2):391-8
pubmed: 20170340
Int J Mol Sci. 2017 Apr 04;18(4):
pubmed: 28375162
Molecules. 2014 Nov 18;19(11):18936-52
pubmed: 25412041
Mol Cell Biochem. 2017 Apr;428(1-2):9-21
pubmed: 28176247
Altern Ther Health Med. 2012 Sep-Oct;18(5):44-9
pubmed: 22894890
Int J Mol Sci. 2017 Sep 14;18(9):
pubmed: 28906474
Int J Pharm. 2011 Nov 25;420(1):133-40
pubmed: 21871547
Eur J Pharmacol. 2011 Nov 30;670(2-3):571-7
pubmed: 21970806
Appl Environ Microbiol. 2005 Dec;71(12):8241-8
pubmed: 16332809
Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F414-F422
pubmed: 28566504
Biochem Biophys Res Commun. 2009 Oct 30;388(4):705-10
pubmed: 19695221
Adv Nutr. 2017 May 15;8(3):423-435
pubmed: 28507008
Oncol Lett. 2018 Feb;15(2):1379-1388
pubmed: 29434828
Biomed Res Int. 2014;2014:309129
pubmed: 25025046
J Ethnopharmacol. 2015 Dec 4;175:528-48
pubmed: 26456328
Neurol Sci. 2014 Apr;35(4):583-8
pubmed: 24166720
Anal Chim Acta. 2017 Aug 1;979:1-23
pubmed: 28599704
Nutrients. 2017 Mar 23;9(4):
pubmed: 28333085
Br J Pharmacol. 2017 Jun;174(11):1450-1463
pubmed: 27685833
Fitoterapia. 2000 Aug;71 Suppl 1:S117-23
pubmed: 10930722
J Psychopharmacol. 2014 May;28(5):498-501
pubmed: 24284476
Arch Pharm Res. 2007 Jan;30(1):13-7
pubmed: 17328236
Food Funct. 2013 Sep;4(9):1339-45
pubmed: 23824306
Toxicol In Vitro. 2014 Apr;28(3):388-96
pubmed: 24362044
Molecules. 2018 Jul 24;23(8):
pubmed: 30042375
J Microbiol Biotechnol. 2015 Sep;25(9):1442-8
pubmed: 25975614
Br J Clin Pharmacol. 2018 Apr;84(4):659-672
pubmed: 29433155
Brain Res. 2013 Jan 25;1492:33-45
pubmed: 23178511
PLoS One. 2013 Aug 29;8(8):e73219
pubmed: 24009741
Arch Toxicol. 2013 Jan;87(1):167-78
pubmed: 22864849
J Exp Neurosci. 2016 Feb 18;10:21-9
pubmed: 26917974
Eur J Pharm Sci. 2017 Oct 15;108:36-49
pubmed: 27939619
Neurosci Lett. 2015 May 6;594:17-22
pubmed: 25800110
Genes Nutr. 2017 Sep 29;12:24
pubmed: 28974991
Eur J Pharmacol. 2016 Mar 5;774:50-4
pubmed: 26826594
Nutr Cancer. 2008;60(2):276-83
pubmed: 18444161
Biochem Pharmacol. 2004 Oct 15;68(8):1631-8
pubmed: 15451406