Pharmaceutical jewelry: Earring patch for transdermal delivery of contraceptive hormone.
Levonorgestrel
Long-acting reversible contraception
Medication adherence
Pharmaceutical jewelry
Skin patch
Transdermal drug delivery
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 05 2019
10 05 2019
Historique:
received:
16
01
2019
revised:
02
03
2019
accepted:
11
03
2019
pubmed:
17
3
2019
medline:
25
8
2020
entrez:
17
3
2019
Statut:
ppublish
Résumé
Lack of adherence to medication dosing schedules is a significant cause of morbidity and mortality with large associated financial costs. This is especially true for contraceptive hormones, which provide almost perfect prevention of pregnancy when used correctly, but have significant failure rates in typical use, due largely to poor adherence. To increase medication acceptability and adherence, we introduce pharmaceutical jewelry, in which a transdermal patch is incorporated into jewelry worn on skin. To demonstrate the approach, we incorporated transdermal patches containing the contraceptive hormone levonorgestrel (LNG) into an earring, a ring, a necklace, and a wrist watch. Transdermal delivery of LNG from earring patches across porcine skin ex vivo achieved a steady state flux of 1.7 μg/cm
Identifiants
pubmed: 30876952
pii: S0168-3659(19)30160-9
doi: 10.1016/j.jconrel.2019.03.011
pii:
doi:
Substances chimiques
Contraceptive Agents, Female
0
Levonorgestrel
5W7SIA7YZW
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
140-145Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.