Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel
Animals
Carcinoma
/ drug therapy
Child
Disease Progression
Drug Resistance, Neoplasm
Female
Gene Fusion
Humans
Intracellular Signaling Peptides and Proteins
/ antagonists & inhibitors
Mice
Mice, Inbred NOD
Mice, SCID
Molecular Targeted Therapy
Piperazines
/ therapeutic use
Protein Kinase Inhibitors
/ therapeutic use
Proto-Oncogene Proteins c-akt
/ antagonists & inhibitors
Pyrimidines
/ therapeutic use
Signal Transduction
/ drug effects
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
23
08
2018
revised:
18
01
2019
accepted:
12
03
2019
pubmed:
17
3
2019
medline:
2
6
2020
entrez:
17
3
2019
Statut:
ppublish
Résumé
Despite the important role of the PI3K/AKT/mTOR axis in the pathogenesis of cancer, to date there have been few functional oncogenic fusions identified involving the
Identifiants
pubmed: 30877085
pii: 2159-8290.CD-18-0953
doi: 10.1158/2159-8290.CD-18-0953
pmc: PMC6497560
mid: NIHMS1524285
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
LAMTOR1 protein, human
0
Piperazines
0
Protein Kinase Inhibitors
0
Pyrimidines
0
ipatasertib
524Y3IB4HQ
AKT1 protein, human
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
605-616Subventions
Organisme : NIH HHS
ID : U54 OD020355
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIH HHS
ID : S10 OD012351
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA217858
Pays : United States
Organisme : NIH HHS
ID : S10 OD021764
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197745
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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