Meningococcal Serogroup A, B, C, W, X, and Y Serum Bactericidal Antibody Assays.

Antibodies, Bacterial / immunology Complement System Proteins / immunology Humans Meningococcal Infections / immunology Meningococcal Vaccines / administration & dosage Neisseria meningitidis / classification Serogroup Serum Bactericidal Antibody Assay / methods Vaccination
Bactericidal Complement Meningococcal Neisseria meningitidis Serum bactericidal antibody

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2019
Historique:
entrez: 17 3 2019
pubmed: 17 3 2019
medline: 5 9 2019
Statut: ppublish

Résumé

Serum bactericidal antibody (SBA) assays measure functional antibody titers against Neisseria meningitidis in sera. Induction of complement-dependent SBA after vaccination with meningococcal polysaccharide or conjugate or protein based vaccines is regarded as the surrogate of protection and thus acceptable evidence of the potential efficacy of these vaccines. This chapter discusses and details SBA assay protocols for measuring the complement-mediated lysis of serogroup A, B, C, W, X, and Y meningococci by human sera, for example, following vaccination or disease.

Identifiants

DOI: 10.1007/978-1-4939-9202-7_12 PMID: 30877677
pubmed: 30877677
doi: 10.1007/978-1-4939-9202-7_12
doi:

Substances chimiques

Antibodies, Bacterial 0
Meningococcal Vaccines 0
Complement System Proteins 9007-36-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

169-179

Auteurs

Jay Lucidarme (J)

Meningococcal Reference Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.

Jennifer Louth (J)

Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.

Kelly Townsend-Payne (K)

Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK.

Ray Borrow (R)

Meningococcal Reference Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK. ray.borrow@phe.gov.uk.
Vaccine Evaluation Unit, National Infection Service, Public Health England, Manchester Medical Microbiology Partnership, Manchester Royal Infirmary, Manchester, UK. ray.borrow@phe.gov.uk.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antibactériens › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Neisseriaceae › Infections à méningocoques › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Vaccins antiméningococciques › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Neisseriaceae › Neisseria › Neisseria meningitidis › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Sérogroupe › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Dosage des anticorps bactéricides du sérum › Meningococcal Serogroup A, B, C, W, X, and Y...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Meningococcal Serogroup A, B, C, W, X, and Y...