Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases.
KAT
N-terminal acetylation
N-terminal acetyltransferase
NAA10
NAA80
NAT
acetylation
actin
lysine acetyltransferase
protein modifications
Journal
Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571
Informations de publication
Date de publication:
21 03 2019
21 03 2019
Historique:
received:
23
11
2018
revised:
23
01
2019
accepted:
04
02
2019
pubmed:
18
3
2019
medline:
15
9
2020
entrez:
18
3
2019
Statut:
ppublish
Résumé
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases (NATs) and expanded the known functions of these enzymes beyond their roles as ribosome-associated co-translational modifiers. For instance, the identification of Golgi- and chloroplast-associated NATs shows that acetylation of N termini also happens post-translationally. In addition, we now appreciate that some NATs are highly specific; for example, a dedicated NAT responsible for post-translational N-terminal acetylation of actin was recently revealed. Other studies have extended NAT function beyond Nt acetylation, including functions as lysine acetyltransferases (KATs) and non-catalytic roles. Finally, emerging studies emphasize the physiological relevance of N-terminal acetylation, including roles in calorie-restriction-induced longevity and pathological α-synuclein aggregation in Parkinson's disease. Combined, the NATs rise as multifunctional proteins, and N-terminal acetylation is gaining recognition as a major cellular regulator.
Identifiants
pubmed: 30878283
pii: S1097-2765(19)30097-8
doi: 10.1016/j.molcel.2019.02.007
pmc: PMC6962057
mid: EMS85409
pii:
doi:
Substances chimiques
N-Terminal Acetyltransferases
EC 2.3.1.88
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1097-1114Subventions
Organisme : European Research Council
ID : 772039
Pays : International
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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