Phasic amygdala and BNST activation during the anticipation of temporally unpredictable social observation in social anxiety disorder patients.
Amygdala
Bed nucleus of stria terminalis
FMRI
Social anxiety disorder
Threat anticipation
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
08
2018
revised:
17
02
2019
accepted:
21
02
2019
pubmed:
18
3
2019
medline:
27
12
2019
entrez:
18
3
2019
Statut:
ppublish
Résumé
Anticipation of potentially threatening social situations is a key process in social anxiety disorder (SAD). In other anxiety disorders, recent research of neural correlates of anticipation of temporally unpredictable threat suggests a temporally dissociable involvement of amygdala and bed nucleus of the stria terminalis (BNST) with phasic amygdala responses and sustained BNST activation. However, the temporal profile of amygdala and BNST responses during temporal unpredictability of threat has not been investigated in patients suffering from SAD. We used functional magnetic resonance imaging (fMRI) to investigate neural activation in the central nucleus of the amygdala (CeA) and the BNST during anticipation of temporally unpredictable aversive (video camera observation) relative to neutral (no camera observation) events in SAD patients compared to healthy controls (HC). For the analysis of fMRI data, we applied two regressors (phasic/sustained) within the same model to detect temporally dissociable brain responses. The aversive condition induced increased anxiety in patients compared to HC. SAD patients compared to HC showed increased phasic activation in the CeA and the BNST for anticipation of aversive relative to neutral events. SAD patients as well as HC showed sustained activity alterations in the BNST for aversive relative to neutral anticipation. No differential activity during sustained threat anticipation in SAD patients compared to HC was found. Taken together, our study reveals both CeA and BNST involvement during threat anticipation in SAD patients. The present results point towards potentially SAD-specific threat processing marked by elevated phasic but not sustained CeA and BNST responses when compared to HC.
Identifiants
pubmed: 30878610
pii: S2213-1582(19)30085-3
doi: 10.1016/j.nicl.2019.101735
pmc: PMC6423472
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101735Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Références
J Anxiety Disord. 2012 Apr;26(3):468-79
pubmed: 22366534
Nat Rev Neurosci. 2015 Jun;16(6):317-31
pubmed: 25991441
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1291-308
pubmed: 19595731
Biol Psychiatry. 1998 Dec 15;44(12):1239-47
pubmed: 9861467
Neuroimage. 2014 Oct 1;99:1-6
pubmed: 24904991
Neurosci Biobehav Rev. 2014 Nov;47:260-80
pubmed: 25124509
J Neurosci. 2016 Aug 3;36(31):8050-63
pubmed: 27488625
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt B):115-122
pubmed: 28642079
Neuroimage. 2018 Feb 1;166:110-116
pubmed: 29107120
Trends Cogn Sci. 2017 May;21(5):357-371
pubmed: 28363681
J Neurosci. 2014 Aug 20;34(34):11261-73
pubmed: 25143607
Nat Commun. 2016 Mar 29;7:10996
pubmed: 27020312
Neuropsychologia. 2010 Oct;48(12):3416-29
pubmed: 20619280
BMC Neurosci. 2009 Dec 10;10:145
pubmed: 20003287
Neurosci Lett. 2019 Feb 6;693:58-67
pubmed: 29195911
Emotion. 2011 Apr;11(2):413-24
pubmed: 21500909
Neuron. 2005 Oct 20;48(2):175-87
pubmed: 16242399
Nat Neurosci. 2015 Oct;18(10):1394-404
pubmed: 26404714
Eur J Pharmacol. 2003 Feb 28;463(1-3):199-216
pubmed: 12600711
J Clin Psychol. 2014 Mar;70(3):260-72
pubmed: 23843207
Anat Embryol (Berl). 2005 Dec;210(5-6):343-52
pubmed: 16208455
Soc Cogn Affect Neurosci. 2017 Nov 1;12(11):1766-1774
pubmed: 28981839
Neuropsychopharmacology. 2016 Jan;41(1):126-41
pubmed: 26105138
Brain Res. 2011 Mar 10;1378:72-83
pubmed: 21215728
Depress Anxiety. 2014 Jun;31(6):472-9
pubmed: 24395386
Neuroreport. 2004 Dec 22;15(18):2701-5
pubmed: 15597038
J Neurosci. 2007 May 30;27(22):5958-66
pubmed: 17537966
Psychol Med. 2017 Nov;47(15):2675-2688
pubmed: 28485259
Psychiatry Res. 2012 Jun 30;202(3):214-23
pubmed: 22809740
J Neurosci. 2016 Aug 3;36(31):8038-49
pubmed: 27488624
Neuropsychopharmacology. 2010 Jan;35(1):105-35
pubmed: 19693004
Hum Brain Mapp. 2016 Mar;37(3):1091-102
pubmed: 26678871
Depress Anxiety. 2015 Sep;32(9):656-63
pubmed: 26115440
J Behav Ther Exp Psychiatry. 2008 Mar;39(1):57-72
pubmed: 17214960
Hum Brain Mapp. 2017 Apr;38(4):2190-2205
pubmed: 28070973
Neurosci Biobehav Rev. 2012 Jan;36(1):459-78
pubmed: 21855571
Soc Cogn Affect Neurosci. 2014 Sep;9(9):1413-8
pubmed: 23938870
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1309-20
pubmed: 19467288
Hum Brain Mapp. 2007 Nov;28(11):1194-205
pubmed: 17266101
Wiley Interdiscip Rev Cogn Sci. 2016 Jul;7(4):218-32
pubmed: 27240280
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
J Behav Ther Exp Psychiatry. 1994 Mar;25(1):49-59
pubmed: 7962581
Ther Clin Risk Manag. 2015 Jan 23;11:115-26
pubmed: 25670901
Cereb Cortex. 2013 Aug;23(8):1874-83
pubmed: 22763169
Trends Neurosci. 2015 May;38(5):319-29
pubmed: 25851307
Cogn Behav Ther. 2007;36(4):193-209
pubmed: 18049945
J Affect Disord. 2017 Feb;209:23-29
pubmed: 27870942
Neuroimage. 2017 Feb 1;146:288-292
pubmed: 27876653
Neuroimage. 2007 Oct 1;37(4):1427-36
pubmed: 17681799
Nat Rev Neurosci. 2013 Jul;14(7):488-501
pubmed: 23783199
Neuroimage. 2005 May 1;25(4):1325-35
pubmed: 15850749
Psychol Med. 2017 Oct;47(14):2502-2512
pubmed: 28464974
Neuroimage. 2011 Mar 1;55(1):389-400
pubmed: 21111828
Cereb Cortex. 2010 Apr;20(4):929-40
pubmed: 19679543
Biol Psychiatry. 2002 Dec 1;52(11):1113-9
pubmed: 12460694
Trends Cogn Sci. 2007 Dec;11(12):499-500
pubmed: 18024182