Podocytic infolding glomerulopathy: two new cases with connective tissue disease and literature review.
Podocytic infolding glomerulopathy
Sjögren’s syndrome
Systemic lupus erythematosus
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
03
12
2018
accepted:
05
03
2019
revised:
17
02
2019
pubmed:
18
3
2019
medline:
4
12
2019
entrez:
18
3
2019
Statut:
ppublish
Résumé
Podocytic infolding glomerulopathy (PIG) is a newly proposed disease entity, and only 29 cases have been reported worldwide so far, characterized by microspheres or microtubular structures or both associated with podocytic infolding into the glomerular basement membrane (GBM) on electron microscopy. We present two new cases of PIG with connective tissue disease (CTD), one with primary Sjögren's syndrome and the other with systemic lupus erythematosus (SLE), and make a systemic review of the literature. In the entire 31 patients of PIG, 24 (77.42%) were women and seven (22.58%) were men, with an average age of 41.2 ± 15.2 (ranging from 14 to 79) years old. Almost two-thirds of patients (67.74%) were diagnosed with CTD, in which 76.19% were SLE. All patients presented with proteinuria and six (19.35%) patients were accompanied with hematuria. Serum creatinine was elevated in six (19.35%) patients. Pathological findings of all patients were consistent with PIG characteristics, and four patients with repeated renal biopsies further provided profound insights.
Identifiants
pubmed: 30879204
doi: 10.1007/s10067-019-04504-6
pii: 10.1007/s10067-019-04504-6
doi:
Substances chimiques
Creatinine
AYI8EX34EU
Types de publication
Case Reports
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1521-1528Subventions
Organisme : Zhejiang Province Public Welfare Technology Application Research Project
ID : 2017C33093
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