[De novo biosynthesis of glycerophospholipids and longevity].
Biosíntesis de novo de glicerofosfolípidos y longevidad.
Diacilglicéridos
Diacylglycerides
Espectrometría de masas
Lipidomics
Lipidómica
Longevidad máxima
Mass spectrometry
Maximum longevity
Journal
Revista espanola de geriatria y gerontologia
ISSN: 1578-1747
Titre abrégé: Rev Esp Geriatr Gerontol
Pays: Spain
ID NLM: 8009022
Informations de publication
Date de publication:
Historique:
received:
01
03
2018
revised:
30
05
2018
accepted:
31
05
2018
entrez:
19
3
2019
pubmed:
19
3
2019
medline:
8
5
2020
Statut:
ppublish
Résumé
The glycerophospholipids, synthesised from diacylglycerol (DAG), are one of the main lipid components of cell membranes. The lipid profile is an optimised feature associated with animal longevity. In this context, the hypothesis is presented that the DAG biosynthesis rate, and thus, the glycerophospholipids content, is related to animal longevity. A plasma lipidomic analysis was performed based on the mass spectrometry of 11 mammalian species with a maximum longevity ranging from 3.5 to 120 years. Lipid identification was based on exact mass, retention time, and isotopic distribution. ANOVA test was applied to differentiate the lipids between animal species. The relationship between these lipids and longevity was carried out with a Spearman correlation. Data was analysed using SPSS and MetaboAnalyst. Among the 1,061 different lipid molecular species found between species, 47 were defined as DAG. Interestingly, 14 of them showed a negative correlation with mammalian maximum longevity. Multivariate statistics revealed that 14 DAGs were enough to define mammalian species and their maximum longevity. Data suggest that long-lived mammalian species have a lower rate of glycerophospholipids synthesis through the de novo pathway, possibly associated with a lower rate of membrane lipid exchange, which in turn is related to lower energy expenditure.
Sections du résumé
BACKGROUND
BACKGROUND
The glycerophospholipids, synthesised from diacylglycerol (DAG), are one of the main lipid components of cell membranes. The lipid profile is an optimised feature associated with animal longevity. In this context, the hypothesis is presented that the DAG biosynthesis rate, and thus, the glycerophospholipids content, is related to animal longevity.
MATERIAL AND METHODS
METHODS
A plasma lipidomic analysis was performed based on the mass spectrometry of 11 mammalian species with a maximum longevity ranging from 3.5 to 120 years. Lipid identification was based on exact mass, retention time, and isotopic distribution. ANOVA test was applied to differentiate the lipids between animal species. The relationship between these lipids and longevity was carried out with a Spearman correlation. Data was analysed using SPSS and MetaboAnalyst.
RESULTS
RESULTS
Among the 1,061 different lipid molecular species found between species, 47 were defined as DAG. Interestingly, 14 of them showed a negative correlation with mammalian maximum longevity. Multivariate statistics revealed that 14 DAGs were enough to define mammalian species and their maximum longevity.
CONCLUSIONS
CONCLUSIONS
Data suggest that long-lived mammalian species have a lower rate of glycerophospholipids synthesis through the de novo pathway, possibly associated with a lower rate of membrane lipid exchange, which in turn is related to lower energy expenditure.
Identifiants
pubmed: 30879491
pii: S0211-139X(18)30580-8
doi: 10.1016/j.regg.2018.05.006
pii:
doi:
Substances chimiques
Glycerophospholipids
0
Types de publication
Journal Article
Langues
spa
Sous-ensembles de citation
IM
Pagination
88-93Informations de copyright
Copyright © 2018 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.