Porphyrin-xylan-coated silica nanoparticles for anticancer photodynamic therapy.
Antineoplastic Agents
/ chemical synthesis
Apoptosis
/ drug effects
Cell Proliferation
/ drug effects
Drug Carriers
/ chemistry
Drug Screening Assays, Antitumor
HCT116 Cells
HT29 Cells
Humans
Molecular Structure
Nanoparticles
/ chemistry
Particle Size
Photochemotherapy
Photosensitizing Agents
/ chemical synthesis
Porphyrins
/ chemical synthesis
Silicon Dioxide
/ chemistry
Surface Properties
Xylans
/ chemistry
Colorectal cancer
Photodynamic therapy
Polysaccharides
Silica nanoparticles
Xylan
Journal
Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156
Informations de publication
Date de publication:
01 Jun 2019
01 Jun 2019
Historique:
received:
04
12
2018
revised:
14
02
2019
accepted:
19
02
2019
entrez:
19
3
2019
pubmed:
19
3
2019
medline:
19
7
2019
Statut:
ppublish
Résumé
Porphyrins are widely used in anticancer photodynamic therapy (PDT). However, low physiological solubility and lack of selectivity towards cancer cells are the main limitations of their clinical use. Nanoparticles are being intensively explored as photosensitizer carriers for PDT to overcome these limitations. The aims of this work are to synthesize core-shell hybrid nanoparticles formed by a silica core and xylan carrying a 5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin (TPPOH) shell, and evaluate their anticancer activity. To afford drug-controlled incorporation and enhance blood circulation, TPPOH was covalently linked to xylan. Different xylans with degrees of substitution in TPPOH ranging from 0.034 to 1.11, were obtained and characterized. Then, the xylan-TPPOH conjugate (PX) was used to coat the silica nanoparticles (PX SNPs). The obtained nano-objects were characterized and their therapeutic potential for photodynamic therapy evaluated against colorectal cancer cell lines. in vitro analysis showed that PX SNPs were 40-fold and 10-fold more effective against HCT116 cells and HT-29 cells respectively compared to free TPPOH.
Identifiants
pubmed: 30879656
pii: S0144-8617(19)30212-7
doi: 10.1016/j.carbpol.2019.02.070
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Drug Carriers
0
Photosensitizing Agents
0
Porphyrins
0
Xylans
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
168-175Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.