Odor perception and hedonics in chronic schizophrenia and in first episode psychosis.
endogenous opioids
negative symptoms
olfaction
schizophrenia
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
19
3
2019
pubmed:
19
3
2019
medline:
19
3
2019
Statut:
epublish
Résumé
The study evaluated olfactory performance and pleasantness rating of odors in patients with first episode psychosis (FEP) and chronic schizophrenia (SCH) with regard to the severity of psychopathological symptoms and plasma β-endorphin concentration. Twenty patients with FEP, 27 with SCH and 29 healthy individuals, were recruited to the research . The University of Pennsylvania Smell Identification Test (UPSIT), subjective odor hedonic judgment and plasma levels of β-endorphin (BE) assay were performed in all participants. Individuals with SCH revealed higher BE concentration than other study groups ( The endogenous morphine system deregulation is observed in first episode psychosis as well as in chronic schizophrenia. In first episode schizophrenia higher beta-endorphin concentration is related to pleasant odor identification deficit.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
The study evaluated olfactory performance and pleasantness rating of odors in patients with first episode psychosis (FEP) and chronic schizophrenia (SCH) with regard to the severity of psychopathological symptoms and plasma β-endorphin concentration.
PATIENTS AND METHODS
METHODS
Twenty patients with FEP, 27 with SCH and 29 healthy individuals, were recruited to the research . The University of Pennsylvania Smell Identification Test (UPSIT), subjective odor hedonic judgment and plasma levels of β-endorphin (BE) assay were performed in all participants.
RESULTS
RESULTS
Individuals with SCH revealed higher BE concentration than other study groups (
CONCLUSION
CONCLUSIONS
The endogenous morphine system deregulation is observed in first episode psychosis as well as in chronic schizophrenia. In first episode schizophrenia higher beta-endorphin concentration is related to pleasant odor identification deficit.
Identifiants
pubmed: 30880989
doi: 10.2147/NDT.S192523
pii: ndt-15-647
pmc: PMC6407904
doi:
Types de publication
Journal Article
Langues
eng
Pagination
647-654Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.
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