Metabolomic analysis of male combat veterans with post traumatic stress disorder.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
07
2018
accepted:
02
03
2019
entrez:
19
3
2019
pubmed:
19
3
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Posttraumatic stress disorder (PTSD) is associated with impaired major domains of psychology and behavior. Individuals with PTSD also have increased co-morbidity with several serious medical conditions, including autoimmune diseases, cardiovascular disease, and diabetes, raising the possibility that systemic pathology associated with PTSD might be identified by metabolomic analysis of blood. We sought to identify metabolites that are altered in male combat veterans with PTSD. In this case-control study, we compared metabolomic profiles from age-matched male combat trauma-exposed veterans from the Iraq and Afghanistan conflicts with PTSD (n = 52) and without PTSD (n = 51) ('Discovery group'). An additional group of 31 PTSD-positive and 31 PTSD-negative male combat-exposed veterans was used for validation of these findings ('Test group'). Plasma metabolite profiles were measured in all subjects using ultrahigh performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We identified key differences between PTSD subjects and controls in pathways related to glycolysis and fatty acid uptake and metabolism in the initial 'Discovery group', consistent with mitochondrial alterations or dysfunction, which were also confirmed in the 'Test group'. Other pathways related to urea cycle and amino acid metabolism were different between PTSD subjects and controls in the 'Discovery' but not in the smaller 'Test' group. These metabolic differences were not explained by comorbid major depression, body mass index, blood glucose, hemoglobin A1c, smoking, or use of analgesics, antidepressants, statins, or anti-inflammatories. These data show replicable, wide-ranging changes in the metabolic profile of combat-exposed males with PTSD, with a suggestion of mitochondrial alterations or dysfunction, that may contribute to the behavioral and somatic phenotypes associated with this disease.
Identifiants
pubmed: 30883584
doi: 10.1371/journal.pone.0213839
pii: PONE-D-18-21199
pmc: PMC6422302
doi:
Substances chimiques
Carbohydrates
0
Fatty Acids
0
Glycated Hemoglobin A
0
Lipids
0
hemoglobin A1c protein, human
0
Hypoxanthine
2TN51YD919
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0213839Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Transl Psychiatry. 2017 Jul 11;7(7):e1169
pubmed: 28696412
J Affect Disord. 2018 Oct 1;238:129-135
pubmed: 29879607
Nat Med. 2014 Apr;20(4):415-8
pubmed: 24608097
Brain Behav Immun. 2011 Jan;25(1):6-13
pubmed: 20934505
Front Biosci (Landmark Ed). 2016 Jan 01;21:769-93
pubmed: 26709805
Front Psychiatry. 2016 Aug 31;7:147
pubmed: 27630582
Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91
pubmed: 18952058
Neurosci Lett. 2009 Apr 10;453(3):219-24
pubmed: 19429039
Transl Psychiatry. 2014 Jun 10;4:e397
pubmed: 26126180
J Anxiety Disord. 2013 Jan;27(1):33-46
pubmed: 23247200
Mol Psychiatry. 2007 Oct;12(10):934-45
pubmed: 17440431
BMC Psychiatry. 2012 Nov 27;12:211
pubmed: 23181934
Mol Neuropsychiatry. 2016 May;2(1):46-59
pubmed: 27606320
Metabolism. 2015 Aug;64(8):926-33
pubmed: 25982700
Lancet Psychiatry. 2015 Nov;2(11):1002-12
pubmed: 26544749
BMC Psychiatry. 2013 Jan 29;13:40
pubmed: 23360282
PLoS One. 2013 Aug 12;8(8):e71721
pubmed: 23951229
Brain. 2013 Oct;136(Pt 10):3038-50
pubmed: 24000005
Glob J Health Sci. 2011 Dec 29;4(1):3-9
pubmed: 22980098
Ann N Y Acad Sci. 1997 Jun 21;821:444-8
pubmed: 9238226
Comput Struct Biotechnol J. 2013 Jan 1;4(5):
pubmed: 23667718
Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S207-14
pubmed: 14677081
Psychiatr Ann. 2016;46:527-532
pubmed: 27990033
Kaohsiung J Med Sci. 2005 Nov;21(11):495-501
pubmed: 16358551
PLoS One. 2014 Mar 14;9(3):e90425
pubmed: 24632812
BMC Psychiatry. 2013 Jan 05;13:8
pubmed: 23289548
Front Immunol. 2016 Jun 06;7:219
pubmed: 27375619
Neurobiol Dis. 2012 Jan;45(1):322-8
pubmed: 21907283
Cell Metab. 2010 Apr 7;11(4):311-9
pubmed: 20374963
Annu Rev Med. 2013;64:291-305
pubmed: 23327524
Oxid Med Cell Longev. 2014;2014:313570
pubmed: 24757497
Ann Intern Med. 2017 Jun 20;166(12):917-918
pubmed: 28437799
PLoS One. 2015 Jan 28;10(1):e0117092
pubmed: 25629821
J Cell Mol Med. 2016 Nov;20(11):2160-2172
pubmed: 27396856
Coll Antropol. 2009 Dec;33 Suppl 2:7-10
pubmed: 20120396
Cardiology. 2014;127(1):1-19
pubmed: 24157651
Exp Neurol. 2016 Oct;284(Pt B):220-229
pubmed: 27246996
PLoS Med. 2006 Aug;3(8):e327
pubmed: 16933966
Prog Lipid Res. 2014 Jan;53:1-17
pubmed: 24334113
Curr Psychiatry Rep. 2017 Aug 29;19(10):75
pubmed: 28852965
Stress. 2019 Jan;22(1):17-26
pubmed: 30084722
Circulation. 2005 Dec 20;112(25):3868-75
pubmed: 16344383
J Neurochem. 2003 Oct;87(2):297-309
pubmed: 14511107
Int J Neuropsychopharmacol. 2012 Jul;15(6):825-40
pubmed: 21798109
Lancet Psychiatry. 2017 Jan;4(1):73-82
pubmed: 27856395
J Clin Invest. 1987 Feb;79(2):588-94
pubmed: 3543056
Alzheimers Dement. 2011 May;7(3):309-17
pubmed: 21075060
Metabolism. 1992 Jan;41(1):22-7
pubmed: 1538640
Nat Med. 2014 Aug;20(8):942-7
pubmed: 24997608
J Head Trauma Rehabil. 2007 Nov-Dec;22(6):318-29
pubmed: 18025964
Neuroscience. 2014 Feb 14;259:223-31
pubmed: 24316471
Crit Rev Clin Lab Sci. 2004;41(1):41-78
pubmed: 15077723
Anal Chem. 2009 Aug 15;81(16):6656-67
pubmed: 19624122
Transl Psychiatry. 2013 Oct 29;3:e320
pubmed: 24169639
Cell Biochem Funct. 2014 Jun;32(4):387-94
pubmed: 24578313
Int J Biol Sci. 2008 Aug 05;4(4):223-35
pubmed: 18690294
J Clin Invest. 2008 Oct;118(10):3503-12
pubmed: 18769631
Biochem Pharmacol. 2002 Sep;64(5-6):893-901
pubmed: 12213584
Cereb Cortex. 2014 Oct;24(10):2784-95
pubmed: 23696276
Neuroimage. 2012 May 15;61(1):98-105
pubmed: 22426350
FASEB J. 2012 Sep;26(9):3649-57
pubmed: 22665389
J Anxiety Disord. 2016 Oct;43:106-117
pubmed: 27449856
Nat Med. 2002 Dec;8(12):1439-44
pubmed: 12447357
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:181-193
pubmed: 30025792
J Neurochem. 1984 Aug;43(2):342-8
pubmed: 6736955
Front Neurol. 2014 Sep 23;5:164
pubmed: 25295026
Brain Behav Immun. 2014 Nov;42:81-8
pubmed: 24929195
Sci Rep. 2018 Feb 22;8(1):3468
pubmed: 29472571
Cell Rep. 2014 Apr 10;7(1):27-34
pubmed: 24685140
Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):715-21
pubmed: 20823773
Front Med. 2013 Mar;7(1):4-13
pubmed: 23377891
Cell Metab. 2011 Jan 5;13(1):11-22
pubmed: 21195345
Mitochondrion. 2014 May;16:7-17
pubmed: 23981537
Brain. 2006 Apr;129(Pt 4):877-86
pubmed: 16464959
Clin Chim Acta. 2005 Jun;356(1-2):35-57
pubmed: 15936302
Trends Pharmacol Sci. 2009 Nov;30(11):557-62
pubmed: 19837462
BMC Med. 2013 May 14;11:126
pubmed: 23672542
Psychoneuroendocrinology. 2017 Aug;82:91-97
pubmed: 28521179
Mol Neuropsychiatry. 2018 Oct;4(2):90-99
pubmed: 30397597
Biol Psychiatry. 2015 Feb 15;77(4):365-74
pubmed: 25104173
Biochem J. 2016 Oct 15;473(20):3421-3449
pubmed: 27729586
Am J Physiol. 1984 May;246(5 Pt 1):E426-9
pubmed: 6720945
PLoS One. 2011;6(7):e21643
pubmed: 21779331
Neurosci Biobehav Rev. 2013 May;37(4):668-80
pubmed: 23415702
J Biol Chem. 2009 Jan 30;284(5):2811-22
pubmed: 19047060
Am J Physiol. 1980 May;238(5):C149-59
pubmed: 6990780
Neurobiol Stress. 2018 Apr 07;8:112-119
pubmed: 29888306
Hum Immunol. 2016 Aug;77(8):652-657
pubmed: 27216157
Int J Geriatr Psychiatry. 2007 May;22(5):418-23
pubmed: 17048218
Curr Opin Clin Nutr Metab Care. 2004 Mar;7(2):151-6
pubmed: 15075705
Neurosci Lett. 2010 Aug 9;480(1):16-20
pubmed: 20546834
EMBO Rep. 2014 May;15(5):518-28
pubmed: 24737872
Expert Opin Pharmacother. 2004 Apr;5(4):977-80
pubmed: 15102580
Am J Epidemiol. 2014 Jul 15;180(2):129-39
pubmed: 24966222
Behav Neurosci. 2009 Feb;123(1):196-205
pubmed: 19170444
Mitochondrion. 2016 Sep;30:197-207
pubmed: 27530300
Curr Alzheimer Res. 2014 Feb;11(2):128-36
pubmed: 24479630
Front Neuroenergetics. 2012 Mar 19;4:5
pubmed: 22457647
Curr Opin Lipidol. 2004 Feb;15(1):13-8
pubmed: 15166803
Mol Psychiatry. 2009 May;14(5):537-45
pubmed: 18180759
Nucleosides Nucleotides Nucleic Acids. 2013;32(1):42-57
pubmed: 23360294
J Lipid Res. 2010 Jun;51(6):1344-53
pubmed: 20129912
PharmaNutrition. 2013 Apr;1(2):41-49
pubmed: 23607087
Psychol Med. 2019 Apr;49(5):791-800
pubmed: 29897034
J Clin Endocrinol Metab. 2006 Sep;91(9):3486-9
pubmed: 16787989
Toxicol Pathol. 2009 Jun;37(4):521-35
pubmed: 19458390
Front Neurol. 2013 Dec 12;4:196
pubmed: 24376434
J Mol Psychiatry. 2015 Feb 08;3(1):2
pubmed: 25848535
Nat Med. 2011 Apr;17(4):448-53
pubmed: 21423183
Int J Psychiatry Med. 2011;41(4):365-77
pubmed: 22238841
Int J Obes. 1990 Oct;14(10):843-55
pubmed: 2269580
Biol Psychiatry. 2010 Dec 1;68(11):999-1006
pubmed: 20951370
Brain. 2008 Feb;131(Pt 2):389-96
pubmed: 18222993
Med Hypotheses. 2014 Aug;83(2):182-5
pubmed: 24875221
J Chem Neuroanat. 2010 Nov;40(3):248-55
pubmed: 20624456
J Psychiatr Res. 2009 Jun;43(9):877-83
pubmed: 19162277
Psychoneuroendocrinology. 2018 Jun;92:123-134
pubmed: 29452766
Circulation. 2012 Aug 28;126(9):1110-20
pubmed: 22927473
Psychoneuroendocrinology. 2009 Oct;34(9):1304-13
pubmed: 19411143
Eur J Immunol. 2011 May;41(5):1196-202
pubmed: 21469137
PLoS One. 2014 May 07;9(5):e96905
pubmed: 24805797
Brain Behav Immun. 2017 Jan;59:260-264
pubmed: 27638184
Curr Pharm Des. 2012;18(35):5608-18
pubmed: 22632476
Am J Psychiatry. 1987 Oct;144(10):1317-9
pubmed: 3661765
Nat Med. 2005 Jan;11(1):90-4
pubmed: 15619630
Depress Anxiety. 1998;7(3):122-5
pubmed: 9656092
Brain Struct Funct. 2015 Jan;220(1):1-12
pubmed: 24248427
Cardiol Rev. 2013 Jan-Feb;21(1):16-22
pubmed: 22717656
Mol Biosyst. 2015 Apr;11(4):980-93
pubmed: 25627823
J Pharm Biomed Anal. 2011 Jun 1;55(3):533-9
pubmed: 21398066
Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5
pubmed: 12883005
J Gen Intern Med. 2011 Jan;26(1):33-9
pubmed: 20853066
J Biol Chem. 2009 Aug 14;284(33):21928-33
pubmed: 19561068
J Atten Disord. 2015 Nov;19(11):954-64
pubmed: 24214970
Behav Brain Res. 2004 Jun 4;152(1):49-57
pubmed: 15135968
Nat Med. 2013 May;19(5):557-66
pubmed: 23652116
Biol Psychiatry. 2018 May 15;83(10):866-875
pubmed: 29628193
Am J Psychiatry. 1997 Feb;154(2):266-8
pubmed: 9016280
J Cheminform. 2010 Oct 18;2(1):9
pubmed: 20955607
Metabolomics. 2005;1(2):101-108
pubmed: 18820733
Curr Top Behav Neurosci. 2012;11:199-251
pubmed: 22294088
Cell. 2010 Sep 3;142(5):687-98
pubmed: 20813258
Depress Anxiety. 2017 May;34(5):391-400
pubmed: 28380289
Crit Rev Biotechnol. 2011 Sep;31(3):264-80
pubmed: 21774633
FASEB J. 2009 May;23(5):1572-83
pubmed: 19141540
Curr Pharm Des. 2014;20(35):5507-9
pubmed: 24606795
J Trauma Stress. 1995 Jan;8(1):75-90
pubmed: 7712061
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33
pubmed: 25071212
Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):259-69
pubmed: 16963244
Behav Brain Funct. 2016 Feb 12;12(1):7
pubmed: 26867941
Neurobiol Dis. 2009 Aug;35(2):165-76
pubmed: 19303440
Brain Behav Immun. 2016 Feb;52:153-160
pubmed: 26515034
Med Hypotheses. 2006;66(6):1205-8
pubmed: 16446049
Metabolomics. 2012 Apr;8(2):253-263
pubmed: 22448154
Psychiatr Ann. 2016 Mar;46(3):173-176
pubmed: 27773950