Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.
Animals
Cell Proliferation
DNA Damage
Female
GATA6 Transcription Factor
/ metabolism
Hair Follicle
/ metabolism
Humans
Lymphoid Enhancer-Binding Factor 1
/ genetics
Male
Mice
Mice, Knockout
MutL Protein Homolog 1
/ genetics
MutS Homolog 2 Protein
/ genetics
Mutation
Sebaceous Gland Neoplasms
/ genetics
Skin Neoplasms
/ genetics
Stem Cells
/ metabolism
beta Catenin
/ genetics
DNA mismatch repair
Gata6
Lef1
sebaceous gland
sebaceous tumors
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
02 05 2019
02 05 2019
Historique:
received:
21
08
2018
revised:
17
02
2019
accepted:
19
02
2019
pubmed:
20
3
2019
medline:
7
1
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Mutations in Lef1 occur in human and mouse sebaceous gland (SG) tumors, but their contribution to carcinogenesis remains unclear. Since Gata6 controls lineage identity in SG, we investigated the link between these two transcription factors. Here, we show that Gata6 is a β-catenin-independent transcriptional target of mutant Lef1. During epidermal development, Gata6 is expressed in a subset of Sox9-positive Lef1-negative hair follicle progenitors that give rise to the upper SG Overexpression of Gata6 by
Identifiants
pubmed: 30886049
pii: embj.2018100526
doi: 10.15252/embj.2018100526
pmc: PMC6484415
pii:
doi:
Substances chimiques
GATA6 Transcription Factor
0
LEF1 protein, human
0
Lef1 protein, mouse
0
Lymphoid Enhancer-Binding Factor 1
0
beta Catenin
0
MSH2 protein, human
EC 3.6.1.3
Msh2 protein, mouse
EC 3.6.1.3
MutL Protein Homolog 1
EC 3.6.1.3
MutS Homolog 2 Protein
EC 3.6.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1100073
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
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