Effects of infection history on dengue virus infection and pathogenicity.
Adolescent
Age Factors
Antibodies, Viral
/ blood
Child
Child, Preschool
Cross Reactions
/ genetics
Dengue
/ blood
Dengue Virus
/ genetics
Female
Host Microbial Interactions
/ immunology
Humans
Male
Nicaragua
/ epidemiology
Prospective Studies
Risk Factors
Serogroup
Vaccination
/ methods
Virulence
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 03 2019
18 03 2019
Historique:
received:
14
08
2018
accepted:
21
02
2019
entrez:
20
3
2019
pubmed:
20
3
2019
medline:
6
4
2019
Statut:
epublish
Résumé
The understanding of immunological interactions among the four dengue virus (DENV) serotypes and their epidemiological implications is often hampered by the lack of individual-level infection history. Using a statistical framework that infers full infection history, we analyze a prospective pediatric cohort in Nicaragua to characterize how infection history modulates the risks of DENV infection and subsequent clinical disease. After controlling for age, one prior infection is associated with 54% lower, while two or more are associated with 91% higher, risk of a new infection, compared to DENV-naive children. Children >8 years old have 55% and 120% higher risks of infection and subsequent disease, respectively, than their younger peers. Among children with ≥1 prior infection, intermediate antibody titers increase, whereas high titers lower, the risk of subsequent infection, compared with undetectable titers. Such complex dependency needs to be considered in the design of dengue vaccines and vaccination strategies.
Identifiants
pubmed: 30886145
doi: 10.1038/s41467-019-09193-y
pii: 10.1038/s41467-019-09193-y
pmc: PMC6423047
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1246Subventions
Organisme : NIAID NIH HHS
ID : R37 AI032042
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106695
Pays : United States
Organisme : NIH HHS
ID : U54-GM111274
Pays : United States
Organisme : NIH HHS
ID : S10 OD020069
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI099631
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM111274
Pays : United States
Organisme : NIH HHS
ID : R37-AI032042
Pays : United States
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