Body composition and nutritional status in malignant pleural mesothelioma: implications for activity levels and quality of life.
Aged
Australia
/ epidemiology
Body Composition
Cross-Sectional Studies
Diet
Exercise
/ physiology
Female
Humans
Lung Neoplasms
/ physiopathology
Male
Malnutrition
/ epidemiology
Mesothelioma
/ physiopathology
Mesothelioma, Malignant
Middle Aged
Nutritional Status
Pleural Neoplasms
/ physiopathology
Prospective Studies
Quality of Life
Sarcopenia
/ epidemiology
Journal
European journal of clinical nutrition
ISSN: 1476-5640
Titre abrégé: Eur J Clin Nutr
Pays: England
ID NLM: 8804070
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
11
2018
accepted:
20
02
2019
revised:
17
02
2019
pubmed:
20
3
2019
medline:
8
8
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Malignant pleural mesothelioma (MPM) is an incurable cancer and optimizing daily physical activity and quality of life are key goals of patient management. Little is known about the prevalence of pre-sarcopenia and malnutrition in MPM or their associations with patient outcomes. This study aimed to determine the prevalence of pre-sarcopenia and malnutrition in MPM and investigate if activity levels and quality of life differed according to body composition and nutritional status. Patients with a diagnosis of MPM were recruited. Pre-sarcopenia was defined as low appendicular skeletal muscle mass (≤ 7.26 kg/m Sixty-one people participated (79% male, median age 69 [IQR 62-74] years and median BMI 25.8 [IQR 24.3-28.4] kg/m Participants with MPM had high rates of pre-sarcopenia and malnutrition. Pre-sarcopenia was associated with poorer activity levels, whilst malnutrition was associated with poorer quality of life. Interventions that aim to address reduced muscle mass and weight loss, should be tested in MPM to assess their impact on patient outcomes.
Sections du résumé
BACKGROUND/OBJECTIVES
Malignant pleural mesothelioma (MPM) is an incurable cancer and optimizing daily physical activity and quality of life are key goals of patient management. Little is known about the prevalence of pre-sarcopenia and malnutrition in MPM or their associations with patient outcomes. This study aimed to determine the prevalence of pre-sarcopenia and malnutrition in MPM and investigate if activity levels and quality of life differed according to body composition and nutritional status.
SUBJECTS/METHODS
Patients with a diagnosis of MPM were recruited. Pre-sarcopenia was defined as low appendicular skeletal muscle mass (≤ 7.26 kg/m
RESULTS
Sixty-one people participated (79% male, median age 69 [IQR 62-74] years and median BMI 25.8 [IQR 24.3-28.4] kg/m
CONCLUSION
Participants with MPM had high rates of pre-sarcopenia and malnutrition. Pre-sarcopenia was associated with poorer activity levels, whilst malnutrition was associated with poorer quality of life. Interventions that aim to address reduced muscle mass and weight loss, should be tested in MPM to assess their impact on patient outcomes.
Identifiants
pubmed: 30886321
doi: 10.1038/s41430-019-0418-9
pii: 10.1038/s41430-019-0418-9
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM