Responses of Plasma Catecholamine, Serotonin, and the Platelet Serotonin Transporter to Cigarette Smoking.

catecholamine cigarette smoking platelet aggregation serotonin serotonin transporter

Journal

Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481

Informations de publication

Date de publication:
2019
Historique:
received: 30 10 2018
accepted: 14 01 2019
entrez: 20 3 2019
pubmed: 20 3 2019
medline: 20 3 2019
Statut: epublish

Résumé

Cigarette smoking is one of the major causes of coronary heart disease with a thirty percent mortality rate in the United States. Cigarette smoking acting on the central nervous system (CNS) to stimulate the sympathetic nervous system (SNS) through, which facilitates the secretion of serotonin (5-HT) and catecholamines to supraphysiological levels in blood. The enhanced levels of 5-HT and catecholamines in smokers' blood are associated with increases in G protein-coupled receptor signaling and serotonylation of small GTPases, which in turn lead to remodeling of cytoskeletal elements to enhance granule secretion and promote unique expression of sialylated

Identifiants

pubmed: 30886568
doi: 10.3389/fnins.2019.00032
pmc: PMC6409334
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

32

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL091196
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD053477
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD058697
Pays : United States

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Auteurs

Curtis Lee Lowery (CL)

Departments of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Donna Woulfe (D)

Department of Biological Sciences, University of Delaware, Newark, DE, United States.

Fusun Kilic (F)

Departments of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

Classifications MeSH