Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions.
Journal
Light, science & applications
ISSN: 2047-7538
Titre abrégé: Light Sci Appl
Pays: England
ID NLM: 101610753
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
10
2018
revised:
21
02
2019
accepted:
22
02
2019
entrez:
20
3
2019
pubmed:
20
3
2019
medline:
20
3
2019
Statut:
epublish
Résumé
Osmotic conditions play an important role in the cell properties of human red blood cells (RBCs), which are crucial for the pathological analysis of some blood diseases such as malaria. Over the past decades, numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes. Here, we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions. Specifically, we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions, where the strength of the optical nonlinearity increases with osmotic pressure on the cells. This tunable nonlinearity is attributed to optical forces, particularly the forward-scattering and gradient forces. Interestingly, in aged blood samples (with lysed cells), a notably different nonlinear behavior is observed due to the presence of free hemoglobin. We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations. Our work on light self-guiding through scattering bio-soft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis.
Identifiants
pubmed: 30886708
doi: 10.1038/s41377-019-0142-1
pii: 142
pmc: PMC6414597
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
Biomed Microdevices. 2015 Apr;17(2):26
pubmed: 25681045
Biotechnol Lett. 2004 Jun;26(12):971-4
pubmed: 15269521
Annu Rev Biophys Biomol Struct. 1994;23:247-85
pubmed: 7919782
Phys Rev Lett. 2017 Aug 4;119(5):058101
pubmed: 28949726
Nano Lett. 2014 May 14;14(5):2498-504
pubmed: 24697412
Biomed Opt Express. 2012 Jul 1;3(7):1594-608
pubmed: 22808431
MRS Bull. 2010 May;35(5):382-388
pubmed: 21151848
Tissue Eng Part B Rev. 2008 Dec;14(4):321-40
pubmed: 18844604
Phys Med Biol. 2013 Jun 7;58(11):R37-61
pubmed: 23666068
Science. 1949 Nov 25;110(2865):543-8
pubmed: 15395398
J Biomed Opt. 2010 Sep-Oct;15(5):055005
pubmed: 21054087
Sci Rep. 2014 Oct 17;4:6659
pubmed: 25322756
Nat Commun. 2015 Mar 11;6:6502
pubmed: 25758026
Cytometry A. 2014 Apr;85(4):332-8
pubmed: 24677669
Light Sci Appl. 2016 Sep 23;5(9):e16148
pubmed: 30167189
Langmuir. 2009 Nov 3;25(21):12495-500
pubmed: 19817352
Biomed Opt Express. 2011 Jul 1;2(7):1803-14
pubmed: 21750759
Phys Rev Lett. 2010 Oct 15;105(16):163906
pubmed: 21230977
Sci Rep. 2015 May 07;5:9768
pubmed: 25950144
Anal Chem. 1997 Jul 15;69(14):2701-10
pubmed: 9341053
Rep Prog Phys. 2012 Aug;75(8):086401
pubmed: 22836010
Biomed Opt Express. 2016 Apr 18;7(5):1889-904
pubmed: 27231629
Sci Rep. 2017 Aug 11;7(1):7928
pubmed: 28801570
Nat Photonics. 2008;2(2):110-115
pubmed: 19492016
Nat Commun. 2013;4:1768
pubmed: 23612309
Int J Mol Sci. 2016 Sep 12;17(9):
pubmed: 27626408
Nat Photonics. 2015;9:563-571
pubmed: 27293480
Appl Opt. 1988 Oct 1;27(19):4027-33
pubmed: 20539510
J Am Chem Soc. 2016 Nov 9;138(44):14586-14591
pubmed: 27786443
Biomed Opt Express. 2014 Dec 11;6(1):112-7
pubmed: 25657879
Electrophoresis. 2008 Dec;29(24):4813-51
pubmed: 19130566
Rev Sci Instrum. 2009 Apr;80(4):043706
pubmed: 19405665
J Biomed Opt. 2017 Sep 1;22(9):91516
pubmed: 28636066
Light Sci Appl. 2016;5:
pubmed: 27818838
Appl Opt. 2000 Nov 1;39(31):5884-9
pubmed: 18354592
Phys Rev Lett. 2013 Nov 22;111(21):218302
pubmed: 24313533
Annu Rev Biophys Bioeng. 1982;11:129-50
pubmed: 7049060
Lab Med. 2018 Oct 11;49(4):298-310
pubmed: 29893945
Biomicrofluidics. 2014 Sep 17;8(5):051501
pubmed: 25332724
Biophys J. 2012 Jul 3;103(1):1-10
pubmed: 22828326