Evaluation of positive patch test reactions using optical coherence tomography: A pilot study.
allergic contact dermatitis
evaluation
optical coherence tomography
patch test
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
ISSN: 1600-0846
Titre abrégé: Skin Res Technol
Pays: England
ID NLM: 9504453
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
21
01
2019
accepted:
16
02
2019
pubmed:
20
3
2019
medline:
11
2
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation. To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative OCT markers that correlate with clinically graded patch test reactions. A total of 25 patch test reactions (7 grade-0, 4 grade-1+, 14 grade-2+) from 7 patients underwent OCT evaluation. Increased epidermal thickness and density was qualitatively observed in grade 1+ and grade 2+ allergic reactions while well-demarcated, signal-free cavities were observed in all grade 2+ reactions. Attenuation coefficients significantly increased across the three reaction grades (2.58 ± 0.092, 2.96 ± 0.121, 3.05 ± 0.065; P < 0.01). Cutaneous blood flow at 0.35 mm monotonically increased with reaction grade severity and blood measurements significantly differed across the three reaction grades (0.053 ± 0.011 mm/s, 0.078 ± 0.015 mm/s, and 0.121 ± 0.008 mm/s; P < 0.01). Attenuation coefficient and cutaneous blood flow at 0.35 mm correlate with clinically graded patch test reactions and hold promise as objective, quantitative markers. OCT may help dermatologists differentiate clinical scoring of allergic reactions in patch test and thereby improve their diagnostic accuracy and interpretation of patch test reactions.
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
625-630Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Clark SC, Zirwas MJ. Management of occupational dermatitis. Dermatol Clin 2009;27(3):365-383, vii-viii.
Lushniak BD. Occupational skin diseases. Prim Care. 2000;27(4):895-916.
Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-S148.
Uyesugi BA, Sheehan MP. Patch testing pearls. Clin Rev Allergy Immunol. 2019;56(1):110-118.
Gambichler T, Moussa G, Sand M, et al. Correlation between clinical scoring of allergic patch test reactions and optical coherence tomography. J Biomed Optics. 2005;10(6):064030.
Zuang V, Archer G, Rona C, Vignini M, Mosca M, Berardesca E. Predicting visual assessment of allergic patch test reactions by non-invasive measurements. Skin Pharmacol Appl Skin Physiol. 2000;13(1):39-51.
Boone MA, Jemec GB, Del Marmol V. Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study. Arch Dermatol Res. 2015;307(1):11-22.
Lindberg M, Matura M. Patch testing. In: Johansen JD, Frosch PJ, Lepoittevin J-P, eds. Contact Dermatitis. Berlin, Heidelberg: Springer Berlin Heidelberg; 2011:439-464.
Gambichler T, Jaedicke V, Terras S. Optical coherence tomography in dermatology: technical and clinical aspects. Arch Dermatol Res. 2011;303(7):457-473.
Welzel J. Optical coherence tomography in dermatology: a review. Skin Res Technol 2001;7(1):1-9.
Wahlberg JELM. Patch testing. In: Frosch JP, Menne′ TLJ, eds. Contact dermatitis, 4th edn. Berlin Heidelberg: Springer-Verlag; 2006:366-390.
Olsen J, Birch-Johansen FH, Themstrup L, Holmes J, Jemec GBE. Dynamic optical coherence tomography of histamine induced wheals. Skin Res Technol 2018;24(4):592-598.
Basko-Plluska JL, Thyssen JP, Schalock PC. Cutaneous and systemic hypersensitivity reactions to metallic implants. Dermatitis. 2011;22(2):65-79.
James WD, Rosenthal LE, Brancaccio RR, Marks JG Jr. American Academy of Dermatology Patch Testing Survey: use and effectiveness of this procedure. J Am Acad Dermatol. 1992;26(6):991-994.
Marks JG, Belsito DV, DeLeo VA, et al. North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. J Am Acad Dermatol. 1998;38(6 Pt 1):911-918.
Agner T, Serup J. Individual and instrumental variations in irritant patch-test reactions-clinical evaluation and quantification by bioengineering methods. Clin Exp Dermatol. 1990;15(1):29-33.
Vestergaard L, Clemmensen OJ, Sorensen FB, Andersen KE. Histological distinction between early allergic and irritant patch test reactions: follicular spongiosis may be characteristic of early allergic contact dermatitis. Contact Dermatitis. 1999;41(4):207-210.
Jacques SL. Optical properties of biological tissues: a review. Phys Med Biol. 2013;58(11):R37-R61.
Meyer MD, McDonald H, Lott J, Watsky KL. Utilization and geographic variation of patch testing among medicare beneficiaries. Dermatitis. 2016;27(4):234-236.