Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11.
Animals
Bone Morphogenetic Proteins
/ genetics
Caco-2 Cells
Cell Culture Techniques
/ methods
Cell Proliferation
Cells, Cultured
Colorectal Neoplasms
/ genetics
Disease Progression
Endothelial Cells
/ chemistry
Endothelium, Lymphatic
/ chemistry
Extracellular Matrix
/ genetics
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Growth Differentiation Factors
/ genetics
Humans
Mice
Neoplasm Transplantation
Tumor Microenvironment
colorectal cancer
extracellular matrix
gene expression profile
lymphatic endothelium
matrisome
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
06
07
2018
revised:
25
01
2019
accepted:
28
02
2019
pubmed:
20
3
2019
medline:
18
1
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC-associated lymphatic endothelium displays a distinct matrisome-associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression. Our data provide new insights into lymphatic contribution to CRC growth, aside from their conventional role as conduits of metastasis.
Substances chimiques
Bone Morphogenetic Proteins
0
GDF11 protein, human
0
Growth Differentiation Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1913-1920Informations de copyright
© 2019 UICC.