Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir

Antineoplastic Agents / chemistry Cell Hypoxia Cell Survival / drug effects Coordination Complexes / chemistry Coumarins / chemistry HeLa Cells Humans Iridium / chemistry Light Neoplasms / drug therapy Photochemotherapy Superoxides / metabolism
conjugation coumarin cyclometalated iridium(III) complexes photodynamic therapy photosensitizer

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
06 05 2019
Historique:
received: 29 01 2019
revised: 18 03 2019
pubmed: 20 3 2019
medline: 29 8 2020
entrez: 20 3 2019
Statut: ppublish

Résumé

Although cyclometalated Ir

Identifiants

DOI: 10.1002/anie.201901268 PMID: 30889300
pubmed: 30889300
doi: 10.1002/anie.201901268
doi:

Substances chimiques

Antineoplastic Agents 0
Coordination Complexes 0
Coumarins 0
Superoxides 11062-77-4
Iridium 44448S9773
coumarin A4VZ22K1WT

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6311-6315

Subventions

Organisme : Departament d'Universitats, Recerca i Societat de la Informació
ID : 2017 FI_B 00617, 2018 FI_B1 00174 and 2019 FI_B2 00167
Pays : International
Organisme : Departament d'Universitats, Recerca i Societat de la Informació
ID : 2017 DI 072
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2015-64319-R
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2017-84779-R
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2014-52658-R
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2016-78454-C2-1-R
Pays : International
Organisme : Czech Science Foundation
ID : 18-09502S
Pays : International
Organisme : Universidad de Murcia
ID : R-1034/2016
Pays : International
Organisme : FEDER funds
ID : CTQ2015-64319-R
Pays : International
Organisme : FEDER funds
ID : CTQ2017-84779-R
Pays : International
Organisme : FEDER funds
ID : CTQ2014-52658-R
Pays : International
Organisme : FEDER funds
ID : CTQ2016-78454-C2-1-R
Pays : International

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Vojtech Novohradsky (V)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.

Anna Rovira (A)

Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, Spain.

Cormac Hally (C)

Institut Químic de Sarrià, Universitat Ramon Llull, Vía Augusta 390, E-08017, Barcelona, Spain.

Alex Galindo (A)

Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, Spain.

Gloria Vigueras (G)

Departamento de Química Inorgánica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), Campus de Espinardo, E-30071, Murcia, Spain.
ORCID: 0000-0002-8449-6968

Albert Gandioso (A)

Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, Spain.

Marie Svitelova (M)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.

Roger Bresolí-Obach (R)

Institut Químic de Sarrià, Universitat Ramon Llull, Vía Augusta 390, E-08017, Barcelona, Spain.

Hana Kostrhunova (H)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.

Lenka Markova (L)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.

Jana Kasparkova (J)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.

Santi Nonell (S)

Institut Químic de Sarrià, Universitat Ramon Llull, Vía Augusta 390, E-08017, Barcelona, Spain.
ORCID: 0000-0002-8900-5291

José Ruiz (J)

Departamento de Química Inorgánica, Universidad de Murcia and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), Campus de Espinardo, E-30071, Murcia, Spain.
ORCID: 0000-0002-0834-337X

Viktor Brabec (V)

Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, CZ-61265, Brno, Czech Republic.
ORCID: 0000-0002-8233-1393

Vicente Marchán (V)

Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, Spain.
ORCID: 0000-0002-1905-2156

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Iridium › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Tumeurs › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Towards Novel Photodynamic Anticancer Agents...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Superoxydes › Towards Novel Photodynamic Anticancer Agents...