Role of Ancillary Techniques in Gynecologic Cytopathology Specimens.
Cervical screening
Dual staining
Genotyping
High-risk human papillomavirus
Methylation
Journal
Acta cytologica
ISSN: 1938-2650
Titre abrégé: Acta Cytol
Pays: Switzerland
ID NLM: 0370307
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
10
2018
accepted:
02
01
2019
pubmed:
20
3
2019
medline:
25
1
2020
entrez:
20
3
2019
Statut:
ppublish
Résumé
The association between high-risk genotypes of human papillomavirus (hr-HPV) and cervical cancer is well established. As hr-HPV testing is rapidly becoming a part of routine cervical cancer screening, either in conjunction with cytology or as primary testing, the management of hr-HPV-positive women has to be tailored in a way that increases the detection of cervical abnormalities while decreasing unnecessary colposcopic biopsies or other invasive procedures. In this review, we discuss the overall utility and strategies of hr-HPV testing, as well as the advantages and limitations of potential triage strategies for hr-HPV-positive women, including HPV genotyping, p16/Ki-67 dual staining, and methylation assays.
Identifiants
pubmed: 30889579
pii: 000496569
doi: 10.1159/000496569
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-70Informations de copyright
© 2019 S. Karger AG, Basel.