Theranostic magnetite cluster@silica@albumin double-shell particles as suitable carriers for water-insoluble drugs and enhanced T2 MR imaging contrast agents.
Cell Death
/ drug effects
Cell Line, Tumor
Cell Survival
/ drug effects
Contrast Media
/ chemistry
Curcumin
/ pharmacology
Drug Carriers
/ chemistry
Drug Liberation
Ferrosoferric Oxide
/ chemistry
Humans
Inhibitory Concentration 50
Iron
/ chemistry
Kinetics
Magnetic Resonance Imaging
Nanoparticles
/ chemistry
Phantoms, Imaging
Serum Albumin, Bovine
/ chemistry
Silicon Dioxide
/ chemistry
Solubility
Theranostic Nanomedicine
Water
/ chemistry
Albumin shell
Drug delivery
MRI
Magnetic silica
Nanobiohybrid particles
Theranostics
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
27
05
2018
revised:
03
12
2018
accepted:
15
02
2019
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
11
7
2019
Statut:
ppublish
Résumé
Design of new multifunctional nanosystems to integrate diagnostic and therapeutic functions is a major area of interest in the field of nanobiotechnology and nanomedicine. In this study, application of a new magnetic multilayered nanobiohybrid system composed of magnetite nanoparticles, silica, and albumin as a theranostic agent was investigated. Once the clusters of magnetite nanoparticles were coated with a silica shell, bovine serum albumin was conjugated to the surface of activated amine-MS particles (BMS). Afterwards, a curcumin-loaded albumin shell was formed on BMS particles (CBBMS). The curcumin loading capacity and efficiency of the nanobiohybrid particles were 93 ± 6 (mg drug/g particles) and 24 ± 1.7 (wt%), respectively. A sustained release profile was observed for the curcumin in PBS which followed the first-order kinetic model. Cytotoxicity evaluation of CBBMS showed a striking reduced IC
Identifiants
pubmed: 30889683
pii: S0928-4931(18)31532-7
doi: 10.1016/j.msec.2019.02.063
pii:
doi:
Substances chimiques
Contrast Media
0
Drug Carriers
0
Water
059QF0KO0R
Serum Albumin, Bovine
27432CM55Q
Silicon Dioxide
7631-86-9
Iron
E1UOL152H7
Curcumin
IT942ZTH98
Ferrosoferric Oxide
XM0M87F357
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1485-1492Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.