Targeting Tumor-Associated Macrophages in Cancer.
cancer
immunotherapy
macrophages
repolarization
trafficking
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
10
01
2019
revised:
11
02
2019
accepted:
12
02
2019
pubmed:
21
3
2019
medline:
15
7
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
Macrophages are phagocytes that serve as a first line of defense against pathogenic insults to tissues. These innate immune cells mount proinflammatory responses to pathogens and repair damaged tissues. However, tumor-associated macrophages (TAMs) express cytokines and chemokines that can suppress antitumor immunity and promote tumor progression. Preclinical studies have identified crucial pathways regulating the recruitment, polarization, and metabolism of TAMs during tumor progression. Moreover, novel therapeutics targeting these pathways can indirectly stimulate cytotoxic T cell activation and recruitment, and synergize with checkpoint inhibitors, chemotherapy and/or radiation therapy in preclinical studies. Thus, clinical trials with therapeutic agents that promote phagocytosis or suppress survival, proliferation, trafficking, or polarization of TAMs are currently underway. These early results offer the promise of improved cancer outcomes.
Identifiants
pubmed: 30890304
pii: S1471-4906(19)30026-2
doi: 10.1016/j.it.2019.02.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
310-327Subventions
Organisme : NCI NIH HHS
ID : R01 CA167426
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE027325
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.