Energy metabolism in cachexia.
adipose tissue
cachexia
inflammation
liver
skeletal muscle
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
17
10
2018
revised:
11
01
2019
accepted:
05
02
2019
pubmed:
21
3
2019
medline:
1
5
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
Cachexia is a wasting disorder that accompanies many chronic diseases including cancer and results from an imbalance of energy requirements and energy uptake. In cancer cachexia, tumor-secreted factors and/or tumor-host interactions cause this imbalance, leading to loss of adipose tissue and skeletal and cardiac muscle, which weakens the body. In this review, we discuss how energy enters the body and is utilized by the different organs, including the gut, liver, adipose tissue, and muscle, and how these organs contribute to the energy wasting observed in cachexia. We also discuss futile cycles both between the organs and within the cells, which are often used to fine-tune energy supply under physiologic conditions. Ultimately, understanding the complex interplay of pathologic energy-wasting circuits in cachexia can bring us closer to identifying effective treatment strategies for this devastating wasting disease.
Identifiants
pubmed: 30890538
pii: embr.201847258
doi: 10.15252/embr.201847258
pmc: PMC6446208
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Authors.
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