Direct targeting of Gα

Animals Cell Line, Tumor Depsipeptides / chemistry Drug Delivery Systems GTP-Binding Protein alpha Subunits / antagonists & inhibitors GTP-Binding Protein alpha Subunits, Gq-G11 / antagonists & inhibitors Gain of Function Mutation HEK293 Cells Humans Melanoma / drug therapy Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins / antagonists & inhibitors Uveal Neoplasms / drug therapy Xenograft Model Antitumor Assays

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
19 03 2019
Historique:
entrez: 21 3 2019
pubmed: 21 3 2019
medline: 15 5 2020
Statut: epublish

Résumé

Somatic gain-of-function mutations of

Identifiants

DOI: 10.1126/scisignal.aau5948 PMID: 30890659
pubmed: 30890659
pii: 12/573/eaau5948
doi: 10.1126/scisignal.aau5948
pii:
doi:

Substances chimiques

Depsipeptides 0
FR900359 0
GNA11 protein, human 0
GNAQ protein, human 0
GTP-Binding Protein alpha Subunits 0
Neoplasm Proteins 0
GTP-Binding Protein alpha Subunits, Gq-G11 EC 3.6.5.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Suvi Annala (S)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
ORCID: 0000-0002-2764-299X

Xiaodong Feng (X)

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0002-2741-5420

Naveen Shridhar (N)

Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.

Funda Eryilmaz (F)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Julian Patt (J)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

JuHee Yang (J)

Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
ORCID: 0000-0001-8934-1714

Eva M Pfeil (EM)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Rodolfo Daniel Cervantes-Villagrana (RD)

Department of Pharmacology, Centro de Investigación y Estudios Avanzados del IPN (Cinvestav-IPN), Apartado Postal 14-740, CDMX 07360, Mexico.
ORCID: 0000-0002-6599-7994

Asuka Inoue (A)

Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980-8578, Japan.

Felix Häberlein (F)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Tanja Slodczyk (T)

Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.

Raphael Reher (R)

Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
ORCID: 0000-0002-5858-1173

Stefan Kehraus (S)

Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Stefania Monteleone (S)

Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.

Ramona Schrage (R)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Nina Heycke (N)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Ulrike Rick (U)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Sandra Engel (S)

Institute of Pharmacology and Clinical Pharmacy, University of Marburg, 35043 Marburg, Germany.

Alexander Pfeifer (A)

Institute of Pharmacology and Toxicology, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.
ORCID: 0000-0001-8805-6831

Peter Kolb (P)

Pharmaceutical Chemistry, Philipps-University Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0000-0003-4089-614X

Gabriele König (G)

Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.

Moritz Bünemann (M)

Institute of Pharmacology and Clinical Pharmacy, University of Marburg, 35043 Marburg, Germany.

Thomas Tüting (T)

Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany.
ORCID: 0000-0001-7146-0934

José Vázquez-Prado (J)

Department of Pharmacology, Centro de Investigación y Estudios Avanzados del IPN (Cinvestav-IPN), Apartado Postal 14-740, CDMX 07360, Mexico.

J Silvio Gutkind (JS)

Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0002-5150-4482

Evelyn Gaffal (E)

Laboratory for Experimental Dermatology, University Hospital Magdeburg, Leipziger Straße 44, 39120 Magdeburg, Germany. evelyn.gaffal@med.ovgu.de kostenis@uni-bonn.de.
ORCID: 0000-0002-4639-9841

Evi Kostenis (E)

Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany. evelyn.gaffal@med.ovgu.de kostenis@uni-bonn.de.
ORCID: 0000-0001-8284-5514

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Direct targeting of Gα
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Direct targeting of Gα
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Depsipeptides › Direct targeting of Gα
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Direct targeting of Gα
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Direct targeting of Gα
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gq-G11 des protéines G › Direct targeting of Gα
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation gain de fonction › Direct targeting of Gα
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Direct targeting of Gα
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Direct targeting of Gα
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Direct targeting of Gα
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Direct targeting of Gα
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › Direct targeting of Gα
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › Direct targeting of Gα
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Direct targeting of Gα
questionsmedicales.fr › Maladies de l'oeil › Maladies de l'uvée › Tumeurs de l'uvée › Direct targeting of Gα
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Direct targeting of Gα