Dysregulation of microRNA metabolism in motor neuron diseases: Novel biomarkers and potential therapeutics.
Motor neuron diseases
RNA therapeutics
microRNAs
Journal
Non-coding RNA research
ISSN: 2468-0540
Titre abrégé: Noncoding RNA Res
Pays: Netherlands
ID NLM: 101688191
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
01
10
2018
revised:
18
12
2018
accepted:
19
12
2018
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
21
3
2019
Statut:
epublish
Résumé
In the last 15 years, several classes of small regulatory RNAs have been identified, uncovering the widespread impact of non-coding elements in the human genome on cell homeostasis and human diseases. MicroRNAs (miRNAs) are a family of small, non-coding RNAs, which exert silencing of mRNA targets in a sequence-dependent fashion. Many miRNAs are specifically expressed in the central nervous system, where they display roles in differentiation, neuronal survival, neuronal plasticity and learning. On the other hand, deregulated miRNA/mRNA expression networks are deeply involved in neurodegeneration. Recent findings suggest a role for miRNAs in the pathogenesis of motor neuron diseases. In particular, cell-specific changes in miRNA profile are involved in the motor neuron disease phenotype and might be implicated in their selective vulnerability. Exploitation of noncoding RNAs, in particular miRNAs, for therapeutic strategies is being assessed for implementing current therapies. In this regard, the neuroprotective potential of certain miRNAs could represent a promising potential tool to improve therapies for motor-neuron diseases. This review focuses on emerging roles of miRNAs in motor neuron diseases and on their impact on neuron life-span and integrity.
Identifiants
pubmed: 30891533
doi: 10.1016/j.ncrna.2018.12.001
pii: S2468-0540(18)30085-4
pmc: PMC6404378
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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