Endocrine disrupting-chemicals and biochemical recurrence of prostate cancer after prostatectomy: A cohort study in Guadeloupe (French West Indies).
Aged
Chlordecone
/ adverse effects
Dichlorodiphenyl Dichloroethylene
/ adverse effects
Disease-Free Survival
Endocrine Disruptors
/ adverse effects
Environmental Pollutants
/ adverse effects
Follow-Up Studies
Guadeloupe
Humans
Insecticides
/ adverse effects
Kallikreins
/ blood
Male
Middle Aged
Neoplasm Recurrence, Local
/ blood
Polychlorinated Biphenyls
/ adverse effects
Prostate-Specific Antigen
/ blood
Prostatectomy
Prostatic Neoplasms
/ mortality
Risk Factors
biochemical recurrence
endocrine-disrupting chemicals
prostate cancer
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
20
01
2019
accepted:
12
03
2019
pubmed:
21
3
2019
medline:
12
2
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer (PCa). Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized PCa. We analyzed the relationship between exposure to the estrogenic chlordecone, the antiandrogenic dichlorodiphenyldichloroethylene (DDE, the main metabolite of the insecticide DDT), and the nondioxin-like polychlorinated biphenyl congener 153 (PCB-153) with mixed estrogenic/antiestrogenic properties and the risk of biochemical recurrence (BCR) after surgery. After a median follow-up of 6.1 years after surgery, we found a significant increase in the risk of BCR, with increasing plasma chlordecone concentration (adjusted hazard ratio = 2.51; 95% confidence interval: 1.39-4.56 for the highest vs. lowest quartile of exposure; p trend = 0.002). We found no associations for DDE or PCB-135. These results shown that exposure to environmental estrogens may negatively influence the outcome of PCa treatment.
Substances chimiques
Endocrine Disruptors
0
Environmental Pollutants
0
Insecticides
0
Dichlorodiphenyl Dichloroethylene
4M7FS82U08
Polychlorinated Biphenyls
DFC2HB4I0K
KLK3 protein, human
EC 3.4.21.-
Kallikreins
EC 3.4.21.-
Prostate-Specific Antigen
EC 3.4.21.77
Chlordecone
RG5XJ88UDF
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
657-663Informations de copyright
© 2019 UICC.
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