Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Acinar Cells
/ drug effects
Animals
Autophagosomes
/ drug effects
Autophagy
/ drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ chemistry
Cell Nucleus
/ metabolism
Ceruletide
/ toxicity
Disease Models, Animal
Humans
Inflammation
/ metabolism
Lysosomes
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Pancreas
/ drug effects
Pancreatitis
/ chemically induced
Phosphorylation
Proteasome Endopeptidase Complex
/ drug effects
TOR Serine-Threonine Kinases
/ antagonists & inhibitors
Autophagy
cerulein
experimental pancreatitis
lysosome
transcription factor
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
22
3
2019
medline:
6
8
2020
entrez:
22
3
2019
Statut:
ppublish
Résumé
Impaired macroautophagy/autophagy has been implicated in experimental and human pancreatitis. However, the transcriptional control governing the autophagy-lysosomal process in pancreatitis is largely unknown. We investigated the role and mechanisms of TFEB (transcription factor EB), a master regulator of lysosomal biogenesis, in the pathogenesis of experimental pancreatitis. We analyzed autophagic flux, TFEB nuclear translocation, lysosomal biogenesis, inflammation and fibrosis in GFP-LC3 transgenic mice, acinar cell-specific
Identifiants
pubmed: 30894069
doi: 10.1080/15548627.2019.1596486
pmc: PMC6844531
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Tcfeb protein, mouse
0
Tcfe3 protein, mouse
136896-33-8
Ceruletide
888Y08971B
mTOR protein, mouse
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1954-1969Subventions
Organisme : NIDDK NIH HHS
ID : P01 DK098108
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA020518
Pays : United States
Organisme : BLRD VA
ID : I01 BX004306
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA024733
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
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