HSB-1 Inhibition and HSF-1 Overexpression Trigger Overlapping Transcriptional Changes To Promote Longevity in
Animals
Caenorhabditis elegans
/ genetics
Caenorhabditis elegans Proteins
/ genetics
Computational Biology
/ methods
Forkhead Transcription Factors
/ metabolism
Gene Expression Profiling
Gene Expression Regulation
Heat Shock Transcription Factors
/ metabolism
Heat-Shock Response
Longevity
/ genetics
Models, Biological
Transcription Factors
/ genetics
Transcriptional Activation
Transcriptome
C. elegans
HSB-1
RNA-Seq
heat shock factor
life span
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
07 05 2019
07 05 2019
Historique:
pubmed:
22
3
2019
medline:
30
11
2019
entrez:
22
3
2019
Statut:
epublish
Résumé
Heat shock factor 1 (HSF-1) is a component of the heat shock response pathway that is induced by cytoplasmic proteotoxic stress. In addition to its role in stress response, HSF-1 also acts as a key regulator of the rate of organismal aging. Overexpression of HSF-1 promotes longevity in
Identifiants
pubmed: 30894454
pii: g3.119.400044
doi: 10.1534/g3.119.400044
pmc: PMC6505166
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Forkhead Transcription Factors
0
Heat Shock Transcription Factors
0
Transcription Factors
0
daf-16 protein, C elegans
0
heat shock factor-1, C elegans
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1679-1692Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG028516
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051439
Pays : United States
Informations de copyright
Copyright © 2019 Sural et al.
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