Tolerogenic Role of Myeloid Suppressor Cells in Organ Transplantation.
MDSC
immune tolerance
immunophenotyping
myeloid cells
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
12
2018
accepted:
14
02
2019
entrez:
22
3
2019
pubmed:
22
3
2019
medline:
4
9
2020
Statut:
epublish
Résumé
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells of myeloid origin with a specific immune inhibitory function that negatively regulates the adaptive immune response. Since MDSC participate in the promotion of tolerance in the context of organ transplantation, therapeutic strategies that regulate the induction and development of MDSC have been the center of scientist attention. Here we review literature regarding induction of MDSC with demonstrated suppressive function among different types of allografts and their mechanism of action. While manipulation of MDSC represents a potential therapeutic approach for the promotion of donor specific tolerance in solid organ transplantation, further characterization of their specific phenotype, which distinguishes MDSC from non-suppressive myeloid cells, and detailed evaluation of the inhibitory mechanism that determines their suppressive function, is necessary for the realistic application of MDSC as biomarkers in health and disease and their potential use as immune cell therapy in organ transplantation.
Identifiants
pubmed: 30894860
doi: 10.3389/fimmu.2019.00374
pmc: PMC6414442
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
374Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139623
Pays : United States
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