New era of research on cancer-associated glycosphingolipids.
cancer marker
cancer-associated antigen
cluster
enzyme-mediated activation of radical sources
ganglioside
glycosphingolipid
lipid raft
Journal
Cancer science
ISSN: 1349-7006
Titre abrégé: Cancer Sci
Pays: England
ID NLM: 101168776
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
06
11
2018
revised:
13
03
2019
accepted:
19
03
2019
pubmed:
22
3
2019
medline:
18
5
2019
entrez:
22
3
2019
Statut:
ppublish
Résumé
Cancer-associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis of their implications in the malignant properties of cancer cells revealed that cancer-associated glycosphingolipids are not only tumor markers, but also functional molecules regulating various signals introduced by membrane microdomains, lipid rafts. In particular, a novel approach, enzyme-mediated activation of radical sources combined with mass spectrometry, has enabled us to clarify the mechanisms by which cancer-associated glycosphingolipids regulate cell signals based on the interaction with membrane molecules and formation of molecular complexes on the cell surface. Novel findings obtained from these approaches are now providing us with insights into the development of new anticancer therapies targeting membrane molecular complexes consisting of cancer-associated glycolipids and their associated membrane molecules. Thus, a new era of cancer-associated glycosphingolipids has now begun.
Identifiants
pubmed: 30895683
doi: 10.1111/cas.14005
pmc: PMC6501054
doi:
Substances chimiques
Biomarkers, Tumor
0
Glycosphingolipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1544-1551Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 15H04696
Informations de copyright
© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
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