Tumor immune microenvironment characteristics of papillary thyroid carcinoma are associated with histopathological aggressiveness and BRAF mutation status.
Adolescent
Adult
Biomarkers, Tumor
CD8 Antigens
Female
Humans
Immunohistochemistry
Leukocytes
/ physiology
Male
Middle Aged
Mutation
Myeloid Cells
/ physiology
Proto-Oncogene Proteins B-raf
/ genetics
T-Lymphocytes
/ immunology
Thyroid Cancer, Papillary
/ genetics
Thyroid Neoplasms
/ genetics
Tumor Microenvironment
/ immunology
Young Adult
biomarker
immune cell
multiplex immunohistochemistry
thyroid cancer
tumor microenvironment
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
31
08
2018
revised:
19
01
2019
accepted:
05
03
2019
pubmed:
22
3
2019
medline:
24
11
2020
entrez:
22
3
2019
Statut:
ppublish
Résumé
Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction. Immune complexity profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 patients with PTC, and were assessed for correlations with aggressive histopathological features based on the presence of lymphovascular invasion and/or extrathyroidal extension, and BRAF V600E mutational status. mIHC revealed two distinct immune clusters stratifying patients: a lymphoid-inflamed group (higher CD8 Distinct immune microenvironments exist in PTC correlating with pathological aggressiveness. Immune-based biomarkers associated with possible tumor-immune interactions may be used for risk stratification.
Sections du résumé
BACKGROUND
Papillary thyroid carcinoma (PTC) follows an indolent course; however, up to 30% of patients develop recurrent disease requiring further treatment. Profiling PTC immune complexity may provide new biomarkers for improved risk prediction.
METHODS
Immune complexity profiles were quantitatively evaluated by multiplex immunohistochemistry (mIHC) in archived tissue sections from 39 patients with PTC, and were assessed for correlations with aggressive histopathological features based on the presence of lymphovascular invasion and/or extrathyroidal extension, and BRAF V600E mutational status.
RESULTS
mIHC revealed two distinct immune clusters stratifying patients: a lymphoid-inflamed group (higher CD8
CONCLUSIONS
Distinct immune microenvironments exist in PTC correlating with pathological aggressiveness. Immune-based biomarkers associated with possible tumor-immune interactions may be used for risk stratification.
Substances chimiques
Biomarkers, Tumor
0
CD8 Antigens
0
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2636-2646Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000128
Pays : United States
Organisme : Oregon Clinical and Translational Research Institute
Pays : International
Organisme : NCATS NIH HHS
ID : #UL1TR000128
Pays : United States
Organisme : Japan Society for the Promotion of Science
ID : 17H07016
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.