Poor risk factor control in outpatients with diabetes mellitus type 2 in Germany: The DIAbetes COhoRtE (DIACORE) study.
Aged
Albumins
/ analysis
Blood Pressure
Cardiovascular Diseases
/ diagnosis
Creatinine
/ blood
Diabetes Mellitus, Type 2
/ complications
Female
Germany
Glomerular Filtration Rate
Glycated Hemoglobin
/ analysis
Humans
Male
Middle Aged
Outpatients
Prospective Studies
Renal Insufficiency, Chronic
/ etiology
Risk Factors
Severity of Illness Index
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
05
2018
accepted:
10
02
2019
entrez:
22
3
2019
pubmed:
22
3
2019
medline:
4
12
2019
Statut:
epublish
Résumé
Patients with diabetes mellitus type 2 (DM2) are at high risk for micro- and macrovascular disease. Here, we explore the degree of traditional risk factor control in the baseline visit of a cohort of DM2 outpatients. DIACORE (DIAbetes COhoRtE) is a prospective cohort study of 3000 adult DM2 outpatients. Here, we present results from the baseline visit. Sociodemographic and anthropometric variables, cardiovascular risk factors, comorbidities and medication were assessed by interview and medical exams. Serum-creatinine based estimated glomerular filtration rate (eGFRcrea) and urinary albumin-creatinine ratio (UACR) were determined for classification of chronic kidney disease (CKD). The proportion of patients with adequate control of traditional risk factors (blood pressure<140/90mmHg, HbA1c<7.5%, LDL<100mg/dl) was calculated in 2892 patients with non-missing data in 9 relevant variables within each KDIGO 2012 CKD class. In the analyzed baseline data (n = 2892, 60.2% men), mean (standard deviation) values for age, DM2 duration and HbA1c were 65.3 (9.3) years, 10.3 (8.4) years and 6.9% (1.1) respectively. Of these 2892 patients, 18.7% had CKD stage 3 or higher, 25.7% had UACR≥30mg/g. Adequate blood pressure, HbA1c and LDL control was achieved in 55.7%, 78.5% and 34.4%, respectively. In 16.4% of patients (473), all three risk factors were below recommended targets. The proportion of adequate risk factor control was similar across KDIGO eGFRcrea classes. Adequate blood pressure and HbA1c control were significantly associated with lower UACR category without and with controlling for other risk factors (p<0.0001, p = 0.0002, respectively). In our study of patients with diabetes mellitus type 2, we observed a low level of risk factor control indicating potential for risk reduction.
Identifiants
pubmed: 30897159
doi: 10.1371/journal.pone.0213157
pii: PONE-D-18-13528
pmc: PMC6428304
doi:
Substances chimiques
Albumins
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0213157Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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