Orthogonally Photocontrolled Non-Autonomous DNA Walker.

Azo Compounds / chemistry DNA / chemistry Humans Light Models, Molecular Nanostructures / chemistry
DNA azo compounds fluorescence nanostructures photochemistry

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
20 05 2019
Historique:
received: 29 01 2019
revised: 12 03 2019
pubmed: 22 3 2019
medline: 9 9 2020
entrez: 22 3 2019
Statut: ppublish

Résumé

There is considerable interest in developing progressively moving devices on the nanoscale, with the aim of using them as parts of programmable therapeutics, smart materials, and nanofactories. Present here is an entirely light-induced DNA walker based on orthogonal photocontrol. Implementing two azobenzene derivatives, S-DM-Azo and DM-Azo, enabled precise coordination of strand displacement reactions that powered a biped walker and guided it along a defined track in a non-autonomous way. This unprecedented type of molecular walker design offers high precision control over the movement in back-and-forth directions as desired, and is regulated solely by the sequence of the irradiation wavelengths. This concept may open new avenues for advancing non-autonomous progressive molecular motors, ultimately facilitating their application at the nanoscale.

Identifiants

DOI: 10.1002/anie.201901272 PMID: 30897257
pubmed: 30897257
doi: 10.1002/anie.201901272
doi:

Substances chimiques

Azo Compounds 0
DNA 9007-49-2
azobenzene F0U1H6UG5C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6948-6951

Subventions

Organisme : Max-Planck-Society
ID : Max Planck Fellowship to M. F.
Pays : International
Organisme : Alexander von Humboldt Foundation
ID : Postdoctoral Fellowship Julian Valero
Pays : International
Organisme : DAAD
ID : Doctoral Fellowship Marko Skugor
Pays : International
Organisme : University of Bonn
ID : Max Planck Fellowship to M.F.
Pays : International
Organisme : JSPS KAKENHI
ID : JP18H03933
Pays : International
Organisme : JSPS A3 Foresight Program
ID : JSPS
Pays : International

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Marko Škugor (M)

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.

Julián Valero (J)

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.
Max-Planck-Fellow Chemische Biologie, Center of Advanced European Studies and Research (caesar), Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
ORCID: 0000-0002-5260-2770

Keiji Murayama (K)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan.
ORCID: 0000-0002-6537-0120

Mathias Centola (M)

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.

Hiroyuki Asanuma (H)

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan.
ORCID: 0000-0001-9903-7847

Michael Famulok (M)

LIMES Chemical Biology Unit, Universität Bonn, Gerhard-Domagk-Straße 1, 53121, Bonn, Germany.
Max-Planck-Fellow Chemische Biologie, Center of Advanced European Studies and Research (caesar), Ludwig-Erhard-Allee 2, 53175, Bonn, Germany.
ORCID: 0000-0001-5878-6577

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés azoïques › Orthogonally Photocontrolled Non-Autonomous DNA Walker.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Orthogonally Photocontrolled Non-Autonomous DNA Walker.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Orthogonally Photocontrolled Non-Autonomous DNA Walker.
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Orthogonally Photocontrolled Non-Autonomous DNA Walker.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Orthogonally Photocontrolled Non-Autonomous DNA Walker.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Orthogonally Photocontrolled Non-Autonomous DNA Walker.