Amnioinfusions to Treat Early Onset Anhydramnios Caused by Renal Anomalies: Background and Rationale for the Renal Anhydramnios Fetal Therapy Trial.
Amnioinfusions
Anhydramnios
Bilateral renal agenesis
Pulmonary hypoplasia
Renal replacement therapy
Journal
Fetal diagnosis and therapy
ISSN: 1421-9964
Titre abrégé: Fetal Diagn Ther
Pays: Switzerland
ID NLM: 9107463
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
09
2018
accepted:
31
01
2019
pubmed:
22
3
2019
medline:
7
1
2020
entrez:
22
3
2019
Statut:
ppublish
Résumé
Anhydramnios caused by early anuria is thought to be universally fatal due to pulmonary hypoplasia. Bilateral renal agenesis and early fetal renal failure leading to anhydramnios constitute early pregnancy renal anhydramnios (EPRA). There have been successful reports of amnioinfusions to promote lung growth in the setting of EPRA. Some of these successfully treated EPRA fetuses have survived the neonatal period, undergone successful dialysis, and subsequently received a kidney transplant. Conversely, there are no reports of untreated EPRA survivors. This early success of amnioinfusions to treat EPRA justifies a rigorous prospective trial. The objective of this study is to provide a review of what is known about fetal therapy for EPRA and describe the Renal Anhydramnios Fetal Therapy trial. We review the epidemiology, pathophysiology, and genetics of EPRA. Furthermore, we have performed systematic review of case reports of treated EPRA. We describe the ethical framework, logistical challenges, and rationale for the current single center (NCT03101891) and planned multicenter trial.
Identifiants
pubmed: 30897573
pii: 000497472
doi: 10.1159/000497472
pmc: PMC8577736
mid: NIHMS1752476
doi:
Banques de données
ClinicalTrials.gov
['NCT03101891']
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
365-372Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK119949
Pays : United States
Informations de copyright
© 2019 S. Karger AG, Basel.
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