A Light-Field Metasurface for High-Resolution Single-Particle Tracking.
Light-field metasurface
Mie resonance
interleaved metasurface
microlens array
point spread function engineering
single-particle tracking
Journal
Nano letters
ISSN: 1530-6992
Titre abrégé: Nano Lett
Pays: United States
ID NLM: 101088070
Informations de publication
Date de publication:
10 04 2019
10 04 2019
Historique:
pubmed:
23
3
2019
medline:
23
3
2019
entrez:
23
3
2019
Statut:
ppublish
Résumé
Three-dimensional (3D) single-particle tracking (SPT) is a key tool for studying dynamic processes in the life sciences. However, conventional optical elements utilizing light fields impose an inherent trade-off between lateral and axial resolution, preventing SPT with high spatiotemporal resolution across an extended volume. We overcome the typical loss in spatial resolution that accompanies light-field-based approaches to obtain 3D information by placing a standard microscope coverslip patterned with a multifunctional, light-field metasurface on a specimen. This approach enables an otherwise unmodified microscope to gather 3D information at an enhanced spatial resolution. We demonstrate simultaneous tracking of multiple fluorescent particles within a large 0.5 × 0.5 × 0.3 mm
Identifiants
pubmed: 30897902
doi: 10.1021/acs.nanolett.8b04673
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng