Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 Jul 2019
01 Jul 2019
Historique:
received:
23
11
2018
revised:
17
01
2019
accepted:
18
03
2019
pubmed:
23
3
2019
medline:
27
8
2019
entrez:
23
3
2019
Statut:
ppublish
Résumé
Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with recurrent loss-of-function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing. To understand the role of PRC2 loss in pathogenesis and identify therapeutic targets, we conducted parallel global epigenomic and proteomic analysis of archival formalin-fixed, paraffin-embedded (FFPE) human MPNST with and without PRC2 loss (MPNST
Identifiants
pubmed: 30898839
pii: 0008-5472.CAN-18-3704
doi: 10.1158/0008-5472.CAN-18-3704
pmc: PMC6637743
mid: NIHMS1525386
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3205-3219Subventions
Organisme : NCI NIH HHS
ID : P01 CA196539
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA076931
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118891
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110174
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001880
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008275
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
©2019 American Association for Cancer Research.
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