Recent advances on the roles of epidermal growth factor receptor in psoriasis.
EGF
EGFR
keratinocytes
psoriasis
Journal
American journal of translational research
ISSN: 1943-8141
Titre abrégé: Am J Transl Res
Pays: United States
ID NLM: 101493030
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
12
2017
accepted:
16
02
2018
entrez:
23
3
2019
pubmed:
23
3
2019
medline:
23
3
2019
Statut:
epublish
Résumé
Epidermal growth factor receptor (EGFR) is a well-characterized receptor tyrosine kinase that involved in many vital activities in cell development, such as cellular homeostasis, proliferation, division, differentiation and apoptosis. Natural activation of EGFR and the concomitant downstream signaling pathways regulation are substantial to maintain normal cellular functions. In recent studies, EGFR was demonstrated to be a fundamental modulator in the control of skin inflammatory responses. Several dermatologic diseases including psoriasis are related to the anomalous activation of EGFR signaling. It has been proved that the expression and activity of EGFR and its endogenous ligands are overexpressed in the active epidermis lesions of psoriasis. Moreover, the remarkable therapeutic improvement of chronic psoriasis in cancer patients during the treatment of EGFR inhibitors or anti-EGFR monoclonal antibodies are also recorded, suggesting that the EGFR-mediated signaling may conduct a crucial role in the pathophysiology of psoriasis.
Types de publication
Journal Article
Review
Langues
eng
Pagination
520-528Subventions
Organisme : NCI NIH HHS
ID : R01 CA196967
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY006769
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY019463
Pays : United States
Organisme : NEI NIH HHS
ID : F32 EY006769
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028560
Pays : United States
Déclaration de conflit d'intérêts
None.
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