Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival.
PTM tubulin
RARRES1
drug resistance
metabolic reprogramming
retinoic acid signaling
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
26 Feb 2019
26 Feb 2019
Historique:
received:
09
10
2018
accepted:
04
12
2018
entrez:
23
3
2019
pubmed:
23
3
2019
medline:
23
3
2019
Statut:
epublish
Résumé
RARRES1, a retinoic acid regulated carboxypeptidase inhibitor associated with fatty acid metabolism, stem cell differentiation and tumorigenesis is among the most commonly methylated loci in multiple cancers but has no known mechanism of action. Here we show that RARRES1 interaction with cytoplasmic carboxypeptidase 2 (CCP2) inhibits tubulin deglutamylation, which in turn regulates the mitochondrial voltage dependent anion channel (VDAC1), mitochondrial membrane potential, AMPK activation, energy balance and metabolically reprograms cells and zebrafish to a more energetic and anabolic phenotype. Depletion of
Identifiants
pubmed: 30899431
doi: 10.18632/oncotarget.26600
pii: 26600
pmc: PMC6422194
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1606-1624Subventions
Organisme : NCI NIH HHS
ID : P30 CA051008
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001431
Pays : United States
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest with the contents of this article.
Références
J Cell Biol. 1999 Aug 23;146(4):855-68
pubmed: 10459019
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12222-6
pubmed: 11050244
Mol Cell Neurosci. 2000 Nov;16(5):578-96
pubmed: 11083920
Curr Opin Cell Biol. 2001 Oct;13(5):555-62
pubmed: 11544023
J Biol Chem. 2002 Sep 13;277(37):33664-9
pubmed: 12087096
J Biol Chem. 2003 May 16;278(20):18063-8
pubmed: 12621037
J Exp Biol. 2003 Jun;206(Pt 12):2049-57
pubmed: 12756287
Obes Res. 2003 Jun;11(6):699-708
pubmed: 12805391
Nat Rev Mol Cell Biol. 2003 Dec;4(12):938-47
pubmed: 14685172
Oncogene. 2004 Mar 18;23(12):2241-9
pubmed: 14691453
Eur J Cell Biol. 1992 Dec;59(2):425-32
pubmed: 1493808
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35
pubmed: 14985505
Cancer Res. 2004 Apr 1;64(7):2411-7
pubmed: 15059893
Science. 2005 Dec 9;310(5754):1642-6
pubmed: 16308421
Eur J Cancer. 2006 Mar;42(4):557-65
pubmed: 16426842
Prostate. 2006 Jun 15;66(9):954-65
pubmed: 16541425
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5787-92
pubmed: 16585511
Nat Genet. 2007 Feb;39(2):178-88
pubmed: 17220891
FASEB J. 2007 Mar;21(3):836-50
pubmed: 17244818
PLoS Genet. 2007 May 25;3(5):e78
pubmed: 17530925
Nature. 2007 Jun 14;447(7146):864-8
pubmed: 17568748
Exp Cell Res. 2008 Jun 10;314(9):1962-72
pubmed: 18374916
J Bioenerg Biomembr. 2008 Jun;40(3):171-82
pubmed: 18683036
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18746-51
pubmed: 19033201
Nat Rev Cancer. 2010 Apr;10(4):267-77
pubmed: 20300106
Annu Rev Pathol. 2011;6:345-64
pubmed: 21073338
Cell. 2010 Nov 12;143(4):564-78
pubmed: 21074048
Nature. 2010 Dec 2;468(7324):701-4
pubmed: 21124456
Nat Rev Cancer. 2011 Feb;11(2):85-95
pubmed: 21258394
Nat Rev Clin Oncol. 2011 Feb 01;8(4):244-50
pubmed: 21283127
Cancer Res. 2011 Feb 15;71(4):1219-28
pubmed: 21303978
J Cell Physiol. 2012 Mar;227(3):1138-47
pubmed: 21567403
FEBS Lett. 2011 Jul 21;585(14):2363-6
pubmed: 21722638
Nat Cell Biol. 2011 Sep 02;13(9):1016-23
pubmed: 21892142
Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):773-86
pubmed: 22086369
Nat Genet. 2013 Feb;45(2):197-201
pubmed: 23263489
J Biol Chem. 2013 Apr 26;288(17):11920-9
pubmed: 23471966
Oncogenesis. 2013 Apr 15;2:e45
pubmed: 23588494
J Biol Chem. 2013 Oct 18;288(42):30454-62
pubmed: 24022483
Mol Biol Cell. 2014 Oct 1;25(19):3017-27
pubmed: 25103237
J Cell Biol. 2014 Aug 18;206(4):461-72
pubmed: 25135932
Semin Cell Dev Biol. 2015 Jan;37:11-9
pubmed: 25307498
Cell Death Differ. 2015 Feb;22(2):248-57
pubmed: 25323588
Nat Cell Biol. 2015 Apr;17(4):351-9
pubmed: 25774832
Nat Commun. 2015 May 27;6:7176
pubmed: 26013497
J Biol Chem. 2015 Oct 30;290(44):26784-9
pubmed: 26306046
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11577-82
pubmed: 26324887
Cell Metab. 2015 Oct 6;22(4):590-605
pubmed: 26365176
Oncotarget. 2015 Oct 13;6(31):30472-86
pubmed: 26421710
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7276-85
pubmed: 26655341
Trends Biochem Sci. 2016 Mar;41(3):211-218
pubmed: 26778478
Cytoskeleton (Hoboken). 2016 Oct;73(10):521-550
pubmed: 26934450
Nature. 2016 Apr 14;532(7598):255-8
pubmed: 27049945
Mol Cancer Res. 2016 Jun;14(6):528-38
pubmed: 27084311
Cell Metab. 2016 May 10;23(5):867-80
pubmed: 27133130
Nat Rev Clin Oncol. 2017 Jan;14(1):11-31
pubmed: 27141887
Breast Cancer Res. 2016 May 24;18(1):55
pubmed: 27220421
J Mol Cell Cardiol. 2016 Aug;97:197-203
pubmed: 27261153
Mol Cells. 2016 Dec;39(12):877-887
pubmed: 27989102
Traffic. 2017 Jun;18(6):336-347
pubmed: 28248450
PLoS One. 2017 Jul 5;12(7):e0180344
pubmed: 28678839
Cancer Lett. 2018 Feb 1;414:71-80
pubmed: 29126912
PLoS One. 2018 Dec 17;13(12):e0208756
pubmed: 30557378
Development. 1995 Feb;121(2):347-57
pubmed: 7768177
J Cell Biol. 1994 Feb;124(4):619-26
pubmed: 8106557
Dev Dyn. 1995 Jul;203(3):253-310
pubmed: 8589427
J Invest Dermatol. 1996 Feb;106(2):269-74
pubmed: 8601727
J Cell Sci. 1996 Jun;109 ( Pt 6):1545-53
pubmed: 8799841
Development. 1996 Dec;123:229-39
pubmed: 9007243
J Cell Sci. 1998 Jan;111 ( Pt 2):171-81
pubmed: 9405300