Optimizing Precision Medicine for Public Health.
genetic disease
genetic therapies
genomic testing
genomics
molecular diagnostics
policy
precision medicine
public health
Journal
Frontiers in public health
ISSN: 2296-2565
Titre abrégé: Front Public Health
Pays: Switzerland
ID NLM: 101616579
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
11
2018
accepted:
14
02
2019
entrez:
23
3
2019
pubmed:
23
3
2019
medline:
23
3
2019
Statut:
epublish
Résumé
Advances in precision medicine have presented challenges to traditional public health decision-making paradigms. Historical methods of allocating healthcare funds based on safety, efficacy, and efficiency, are challenged in a healthcare delivery model that focuses on individualized variations in pathology that form the core of precision medicine. Public health policy and decision-making must adapt to this new frontier of healthcare delivery to ensure that the broad public health goals of reducing healthcare disparities and improving the health of populations are achieved, through effective and equitable allocation of healthcare funds. This paper discusses contemporary applications of precision medicine, and the potential impacts of these on public health policy and decision-making, with particular focus on patients living with rare diseases and rare cancers. The authors then reconcile these, presenting precision public health as the bridge between these seemingly competing fields.
Identifiants
pubmed: 30899755
doi: 10.3389/fpubh.2019.00042
pmc: PMC6416195
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
42Références
N Engl J Med. 2003 Aug 7;349(6):562-9
pubmed: 12904522
Health Econ. 2006 Jul;15(7):677-87
pubmed: 16491461
Adm Policy Ment Health. 2009 Jan;36(1):24-34
pubmed: 19104929
Value Health. 2009 Mar;12 Suppl 1:S5-9
pubmed: 19250132
Can J Clin Pharmacol. 2009 Summer;16(2):e273-81; discussion e282-4
pubmed: 19439771
Int J Environ Res Public Health. 2009 Dec;6(12):2950-66
pubmed: 20049237
Orphanet J Rare Dis. 2011 Jun 17;6:42
pubmed: 21682893
Prev Med. 2013 Nov;57(5):477-82
pubmed: 23827720
Twin Res Hum Genet. 2013 Aug;16(4):840-4
pubmed: 23870680
Annu Rev Med. 2014;65:405-15
pubmed: 24422576
Semin Oncol Nurs. 2014 May;30(2):109-16
pubmed: 24794084
J Gen Intern Med. 2014 Aug;29 Suppl 3:S774-9
pubmed: 25029973
Science. 2014 Sep 5;345(6201):1184-1188
pubmed: 25123483
J Clin Oncol. 2015 Mar 20;33(9):975-7
pubmed: 25667288
JAMA. 2015 Jun 2;313(21):2119-20
pubmed: 25928209
Cell Cycle. 2015;14(14):2219-21
pubmed: 26030337
J Law Med Ethics. 2015 Fall;43(3):486-501
pubmed: 26479558
Curr Opin Oncol. 2016 Jan;28(1):83-7
pubmed: 26569425
ACM Comput Surv. 2015 Sep;48(1):
pubmed: 26640318
Science. 2016 Jan 22;351(6271):400-3
pubmed: 26721683
Appl Transl Genom. 2014 Sep 16;3(4):111-5
pubmed: 27294025
Nature. 2016 Sep 07;537(7619):S63
pubmed: 27602743
JAMA. 2016 Oct 25;316(16):1659-1660
pubmed: 27669484
Am J Med Genet A. 2017 Jan;173(1):264-267
pubmed: 27753196
Genet Med. 2017 Jul;19(7):743-750
pubmed: 27929525
Front Public Health. 2017 Apr 10;5:31
pubmed: 28443272
Nature. 2017 Aug 24;548(7668):413-419
pubmed: 28783728
Clin Pharmacol Ther. 2017 Dec;102(6):934-941
pubmed: 28795401
J Community Genet. 2018 Apr;9(2):103-116
pubmed: 28952070
Eur J Public Health. 2017 Oct 1;27(suppl_4):36-39
pubmed: 29028243
Cancer Res. 2017 Dec 1;77(23):6473-6479
pubmed: 29162615
N Engl J Med. 2017 Dec 28;377(26):2545-2554
pubmed: 29226764
Genet Med. 2018 Jun;20(6):574-582
pubmed: 29240076
Science. 2018 Feb 23;359(6378):926-930
pubmed: 29348365
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Ann Oncol. 2018 Apr 1;29(4):784-787
pubmed: 29462260
BMJ. 2018 Mar 8;360:k698
pubmed: 29519932
Hum Mol Genet. 2018 May 1;27(R1):R8-R13
pubmed: 29522190
Elife. 2018 Mar 20;7:
pubmed: 29557778
Front Public Health. 2018 Apr 30;6:121
pubmed: 29761096
NPJ Precis Oncol. 2017 Apr 24;1(1):12
pubmed: 29872700
Int J Hematol. 2018 Oct;108(4):402-410
pubmed: 29959746
Expert Rev Pharmacoecon Outcomes Res. 2018 Dec;18(6):593-599
pubmed: 30052095
J Transl Med. 2018 Jul 27;16(1):211
pubmed: 30053823
Sci Rep. 2018 Aug 2;8(1):11631
pubmed: 30072705
J Clin Oncol. 2018 Oct 1;36(28):2845-2853
pubmed: 30125215
Br J Cancer. 2018 Aug;119(5):615-621
pubmed: 30131550
Science. 2018 Oct 5;362(6410):86-91
pubmed: 30166439
Prog Retin Eye Res. 2019 Jan;68:31-53
pubmed: 30170104
JACC Basic Transl Sci. 2018 Aug 28;3(4):545-549
pubmed: 30175278
Ther Adv Med Oncol. 2018 Aug 29;10:1758835918794630
pubmed: 30181785
N Engl J Med. 2018 Oct 11;379(15):1398-1400
pubmed: 30184442
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Front Public Health. 2018 Sep 04;6:247
pubmed: 30234091
Gastroenterology. 2019 Jan;156(1):108-118.e4
pubmed: 30240661
J Psychiatr Res. 2019 Jan 4;111:59-67
pubmed: 30677646