Systemic clearance of p16
ADAMTS4 Protein
/ metabolism
Aggrecans
/ metabolism
Aging
/ pathology
Animals
Cell Death
/ physiology
Cellular Senescence
/ genetics
Cyclin-Dependent Kinase Inhibitor p16
/ genetics
Ganciclovir
/ pharmacology
Interleukin-6
/ metabolism
Intervertebral Disc
/ cytology
Intervertebral Disc Degeneration
/ metabolism
Matrix Metalloproteinase 13
/ metabolism
Mice
Mice, Transgenic
Proteoglycans
/ metabolism
Thymidine Kinase
/ genetics
aggrecanolysis
aging
cellular senescence
intervertebral disc
p16Ink4a
proteoglycan
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
15
01
2019
accepted:
27
01
2019
pubmed:
23
3
2019
medline:
27
6
2020
entrez:
23
3
2019
Statut:
ppublish
Résumé
Age-related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically secrete numerous inflammatory molecules and proteases, has been reported to cause decline in the health and function of multiple tissues with age. Although senescent cells have been reported to increase in intervertebral degeneration (IDD), it is not known whether they are causative in age-related IDD. The study aimed to elucidate whether a causal relationship exists between cellular senescence and age-related IDD. To examine the impact of senescent cells on age-associated IDD, we used p16-3MR transgenic mice, which enables the selective removal of p16 The findings of this study suggest that systemic reduction in the number of senescent cells ameliorates multiple age-associated changes within the disc tissue. Cellular senescence could therefore serve as a therapeutic target to restore the health of disc tissue that deteriorates with age.
Identifiants
pubmed: 30900385
doi: 10.1111/acel.12927
pmc: PMC6516165
doi:
Substances chimiques
Aggrecans
0
Cyclin-Dependent Kinase Inhibitor p16
0
Interleukin-6
0
Proteoglycans
0
Thymidine Kinase
EC 2.7.1.21
Matrix Metalloproteinase 13
EC 3.4.24.-
Mmp13 protein, mouse
EC 3.4.24.-
ADAMTS4 Protein
EC 3.4.24.82
Adamts4 protein, mouse
EC 3.4.24.82
Ganciclovir
P9G3CKZ4P5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12927Subventions
Organisme : NIH HHS
ID : S10 OD019973
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG044376
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211963
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG009909
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122023
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG009909
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG056278
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG043376
Pays : United States
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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